Kalkitoxin Inhibits Angiogenesis, Disrupts Cellular Hypoxic Signaling, and Blocks Mitochondrial Electron Transport in Tumor Cells

The biologically active lipopeptide kalkitoxin was previously isolated from the marine cyanobacterium Moorea producens (Lyngbya majuscula). Kalkitoxin exhibited N-methyl-d-aspartate (NMDA)-mediated neurotoxicity and acted as an inhibitory ligand for voltage-sensitive sodium channels in cultured rat...

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Detalles Bibliográficos
Autores principales: Morgan, J. Brian, Liu, Yang, Coothankandaswamy, Veena, Mahdi, Fakhri, Jekabsons, Mika B., Gerwick, William H., Valeriote, Frederick A., Zhou, Yu-Dong, Nagle, Dale G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4377999/
https://www.ncbi.nlm.nih.gov/pubmed/25803180
http://dx.doi.org/10.3390/md13031552

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4377999/
https://www.ncbi.nlm.nih.gov/pubmed/25803180
http://dx.doi.org/10.3390/md13031552

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