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Acute liver failure in pregnancy: Challenges and management
Acute liver failure (ALF) in pregnancy negatively affects both maternal and foetal outcome. The spectrum of liver disease in pregnancy may range from mild asymptomatic transaminitis to fatal and irreversible deterioration in liver functions leading to significant morbidity and even mortality. In thi...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Medknow Publications & Media Pvt Ltd
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4378074/ https://www.ncbi.nlm.nih.gov/pubmed/25838585 http://dx.doi.org/10.4103/0019-5049.153035 |
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author | Pandey, Chandra Kant Karna, Sunaina Tejpal Pandey, Vijay Kant Tandon, Manish |
author_facet | Pandey, Chandra Kant Karna, Sunaina Tejpal Pandey, Vijay Kant Tandon, Manish |
author_sort | Pandey, Chandra Kant |
collection | PubMed |
description | Acute liver failure (ALF) in pregnancy negatively affects both maternal and foetal outcome. The spectrum of liver disease in pregnancy may range from mild asymptomatic transaminitis to fatal and irreversible deterioration in liver functions leading to significant morbidity and even mortality. In this comprehensive review, we searched articles published as review articles, clinical trials, and case series in the Medline from 1970 to 2012. The overall outcome of ALF in pregnancy depends on the aetiology, timely diagnosis, prompt management, and early referral to a centre equipped in managing medical or obstetric complication. The foetal outcome is affected by the stage of pregnancy in which the mother has a deterioration of the liver function, with a worst prognosis associated with first or second-trimester liver failure. When ALF complicates pregnancy, liver transplantation is the one of the viable options. Management protocols need to be individualised for each case keeping in mind the risk versus benefit to both the mother and the foetus. |
format | Online Article Text |
id | pubmed-4378074 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-43780742015-04-02 Acute liver failure in pregnancy: Challenges and management Pandey, Chandra Kant Karna, Sunaina Tejpal Pandey, Vijay Kant Tandon, Manish Indian J Anaesth Review Article Acute liver failure (ALF) in pregnancy negatively affects both maternal and foetal outcome. The spectrum of liver disease in pregnancy may range from mild asymptomatic transaminitis to fatal and irreversible deterioration in liver functions leading to significant morbidity and even mortality. In this comprehensive review, we searched articles published as review articles, clinical trials, and case series in the Medline from 1970 to 2012. The overall outcome of ALF in pregnancy depends on the aetiology, timely diagnosis, prompt management, and early referral to a centre equipped in managing medical or obstetric complication. The foetal outcome is affected by the stage of pregnancy in which the mother has a deterioration of the liver function, with a worst prognosis associated with first or second-trimester liver failure. When ALF complicates pregnancy, liver transplantation is the one of the viable options. Management protocols need to be individualised for each case keeping in mind the risk versus benefit to both the mother and the foetus. Medknow Publications & Media Pvt Ltd 2015-03 /pmc/articles/PMC4378074/ /pubmed/25838585 http://dx.doi.org/10.4103/0019-5049.153035 Text en Copyright: © Indian Journal of Anaesthesia http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Pandey, Chandra Kant Karna, Sunaina Tejpal Pandey, Vijay Kant Tandon, Manish Acute liver failure in pregnancy: Challenges and management |
title | Acute liver failure in pregnancy: Challenges and management |
title_full | Acute liver failure in pregnancy: Challenges and management |
title_fullStr | Acute liver failure in pregnancy: Challenges and management |
title_full_unstemmed | Acute liver failure in pregnancy: Challenges and management |
title_short | Acute liver failure in pregnancy: Challenges and management |
title_sort | acute liver failure in pregnancy: challenges and management |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4378074/ https://www.ncbi.nlm.nih.gov/pubmed/25838585 http://dx.doi.org/10.4103/0019-5049.153035 |
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