Serum and Synovial Fluid Levels of CCL18 are Correlated with Radiographic Grading of Knee Osteoarthritis

BACKGROUND: Chemokines are involved in the pathogenesis of osteoarthritis (OA). CCL18, a member of the chemokines family, is observed in synovial fluid (SF) of OA patients. The aim of this study was to determine the association between CCL18 levels in serum and SF with radiographic knee OA. MATERIAL...

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Detalles Bibliográficos
Autores principales: Zhou, Yun, Chen, Juwu, Yang, Guohui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Scientific Literature, Inc. 2015
Materias:
Clinical Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4378228/
https://www.ncbi.nlm.nih.gov/pubmed/25794928
http://dx.doi.org/10.12659/MSM.892409
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author Zhou, Yun
Chen, Juwu
Yang, Guohui
author_facet Zhou, Yun
Chen, Juwu
Yang, Guohui
author_sort Zhou, Yun
collection PubMed
description BACKGROUND: Chemokines are involved in the pathogenesis of osteoarthritis (OA). CCL18, a member of the chemokines family, is observed in synovial fluid (SF) of OA patients. The aim of this study was to determine the association between CCL18 levels in serum and SF with radiographic knee OA. MATERIAL/METHODS: This study was conducted in a population of 308 patients with knee OA. The radiological knee OA was graded by the Kellgren-Lawrence grading system. RESULTS: Serum levels of CCL18 in knee OA patients were markedly higher than those in healthy controls. Serum and SF levels of CCL18 increased with the severity of KL grades and were correlated with disease severity. CONCLUSIONS: The CCL18 levels in serum and SF are correlated with the severity of OA.
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spelling pubmed-43782282015-04-06 Serum and Synovial Fluid Levels of CCL18 are Correlated with Radiographic Grading of Knee Osteoarthritis Zhou, Yun Chen, Juwu Yang, Guohui Med Sci Monit Clinical Research BACKGROUND: Chemokines are involved in the pathogenesis of osteoarthritis (OA). CCL18, a member of the chemokines family, is observed in synovial fluid (SF) of OA patients. The aim of this study was to determine the association between CCL18 levels in serum and SF with radiographic knee OA. MATERIAL/METHODS: This study was conducted in a population of 308 patients with knee OA. The radiological knee OA was graded by the Kellgren-Lawrence grading system. RESULTS: Serum levels of CCL18 in knee OA patients were markedly higher than those in healthy controls. Serum and SF levels of CCL18 increased with the severity of KL grades and were correlated with disease severity. CONCLUSIONS: The CCL18 levels in serum and SF are correlated with the severity of OA. International Scientific Literature, Inc. 2015-03-21 /pmc/articles/PMC4378228/ /pubmed/25794928 http://dx.doi.org/10.12659/MSM.892409 Text en © Med Sci Monit, 2015 This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License
spellingShingle Clinical Research
Zhou, Yun
Chen, Juwu
Yang, Guohui
Serum and Synovial Fluid Levels of CCL18 are Correlated with Radiographic Grading of Knee Osteoarthritis
title Serum and Synovial Fluid Levels of CCL18 are Correlated with Radiographic Grading of Knee Osteoarthritis
title_full Serum and Synovial Fluid Levels of CCL18 are Correlated with Radiographic Grading of Knee Osteoarthritis
title_fullStr Serum and Synovial Fluid Levels of CCL18 are Correlated with Radiographic Grading of Knee Osteoarthritis
title_full_unstemmed Serum and Synovial Fluid Levels of CCL18 are Correlated with Radiographic Grading of Knee Osteoarthritis
title_short Serum and Synovial Fluid Levels of CCL18 are Correlated with Radiographic Grading of Knee Osteoarthritis
title_sort serum and synovial fluid levels of ccl18 are correlated with radiographic grading of knee osteoarthritis
topic Clinical Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4378228/
https://www.ncbi.nlm.nih.gov/pubmed/25794928
http://dx.doi.org/10.12659/MSM.892409
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AT chenjuwu serumandsynovialfluidlevelsofccl18arecorrelatedwithradiographicgradingofkneeosteoarthritis
AT yangguohui serumandsynovialfluidlevelsofccl18arecorrelatedwithradiographicgradingofkneeosteoarthritis

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