Structure-Based Evaluation of Non-nucleoside Inhibitors with Improved Potency and Solubility That Target HIV Reverse Transcriptase Variants

[Image: see text] The development of novel non-nucleoside inhibitors (NNRTIs) with activity against variants of HIV reverse transcriptase (RT) is crucial for overcoming treatment failure. The NNRTIs bind in an allosteric pocket in RT ∼10 Å away from the active site. Earlier analogues of the catechol...

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Detalles Bibliográficos
Autores principales: Frey, Kathleen M., Puleo, David E., Spasov, Krasimir A., Bollini, Mariella, Jorgensen, William L., Anderson, Karen S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2015
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4378236/
https://www.ncbi.nlm.nih.gov/pubmed/25700160
http://dx.doi.org/10.1021/jm501908a

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