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NPC1L1 knockout protects against colitis-associated tumorigenesis in mice
BACKGROUND: Colorectal cancer is strongly associated with lipid metabolism. NPC1L1, a sterol transporter, plays a key role in modulating lipid homeostasis in vivo. Its inhibitor, ezetimibe, began to be used clinically to lower cholesterol and this caused the great debate on its role in causing carci...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4378275/ https://www.ncbi.nlm.nih.gov/pubmed/25881076 http://dx.doi.org/10.1186/s12885-015-1230-0 |