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NPC1L1 knockout protects against colitis-associated tumorigenesis in mice

BACKGROUND: Colorectal cancer is strongly associated with lipid metabolism. NPC1L1, a sterol transporter, plays a key role in modulating lipid homeostasis in vivo. Its inhibitor, ezetimibe, began to be used clinically to lower cholesterol and this caused the great debate on its role in causing carci...

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Detalles Bibliográficos
Autores principales:	He, Jianming, Shin, Hyunsu, Wei, Xing, Kadegowda, Anil Kumar G, Chen, Rui, Xie, Sandy Krystal
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4378275/ https://www.ncbi.nlm.nih.gov/pubmed/25881076 http://dx.doi.org/10.1186/s12885-015-1230-0

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