Subunit disassembly and inhibition of TNFα by a semi-synthetic bicyclic peptide

Macrocyclic peptides are potentially a source of powerful drugs, but their de novo discovery remains challenging. Here we describe the discovery of a high-affinity (K(d) = 10 nM) peptide macrocycle (M21) against human tumor necrosis factor-alpha (hTNFα), a key drug target in the treatment of inflamm...

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Detalles Bibliográficos
Autores principales: Luzi, Stefan, Kondo, Yasushi, Bernard, Elise, Stadler, Lukas K. J., Vaysburd, Marina, Winter, Greg, Holliger, Philipp
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2015
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4378371/
https://www.ncbi.nlm.nih.gov/pubmed/25614525
http://dx.doi.org/10.1093/protein/gzu055

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4378371/
https://www.ncbi.nlm.nih.gov/pubmed/25614525
http://dx.doi.org/10.1093/protein/gzu055

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