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Subunit disassembly and inhibition of TNFα by a semi-synthetic bicyclic peptide
Macrocyclic peptides are potentially a source of powerful drugs, but their de novo discovery remains challenging. Here we describe the discovery of a high-affinity (K(d) = 10 nM) peptide macrocycle (M21) against human tumor necrosis factor-alpha (hTNFα), a key drug target in the treatment of inflamm...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4378371/ https://www.ncbi.nlm.nih.gov/pubmed/25614525 http://dx.doi.org/10.1093/protein/gzu055 |