Pathogenicity of 2 Porcine Deltacoronavirus Strains in Gnotobiotic Pigs

To verify whether porcine deltacoronavirus infection induces disease, we inoculated gnotobiotic pigs with 2 virus strains (OH-FD22 and OH-FD100) identified by 2 specific reverse transcription PCRs. At 21–120 h postinoculation, pigs exhibited severe diarrhea, vomiting, fecal shedding of virus, and se...

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Autores principales: Jung, Kwonil, Hu, Hui, Eyerly, Bryan, Lu, Zhongyan, Chepngeno, Juliet, Saif, Linda J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Centers for Disease Control and Prevention 2015
Materias:
Dispatch
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4378491/
https://www.ncbi.nlm.nih.gov/pubmed/25811229
http://dx.doi.org/10.3201/eid2104.141859
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author Jung, Kwonil
Hu, Hui
Eyerly, Bryan
Lu, Zhongyan
Chepngeno, Juliet
Saif, Linda J.
author_facet Jung, Kwonil
Hu, Hui
Eyerly, Bryan
Lu, Zhongyan
Chepngeno, Juliet
Saif, Linda J.
author_sort Jung, Kwonil
collection PubMed
description To verify whether porcine deltacoronavirus infection induces disease, we inoculated gnotobiotic pigs with 2 virus strains (OH-FD22 and OH-FD100) identified by 2 specific reverse transcription PCRs. At 21–120 h postinoculation, pigs exhibited severe diarrhea, vomiting, fecal shedding of virus, and severe atrophic enteritis. These findings confirm that these 2 strains are enteropathogenic in pigs.
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spelling pubmed-43784912015-04-01 Pathogenicity of 2 Porcine Deltacoronavirus Strains in Gnotobiotic Pigs Jung, Kwonil Hu, Hui Eyerly, Bryan Lu, Zhongyan Chepngeno, Juliet Saif, Linda J. Emerg Infect Dis Dispatch To verify whether porcine deltacoronavirus infection induces disease, we inoculated gnotobiotic pigs with 2 virus strains (OH-FD22 and OH-FD100) identified by 2 specific reverse transcription PCRs. At 21–120 h postinoculation, pigs exhibited severe diarrhea, vomiting, fecal shedding of virus, and severe atrophic enteritis. These findings confirm that these 2 strains are enteropathogenic in pigs. Centers for Disease Control and Prevention 2015-04 /pmc/articles/PMC4378491/ /pubmed/25811229 http://dx.doi.org/10.3201/eid2104.141859 Text en https://creativecommons.org/licenses/by/4.0/This is a publication of the U.S. Government. This publication is in the public domain and is therefore without copyright. All text from this work may be reprinted freely. Use of these materials should be properly cited.
spellingShingle Dispatch
Jung, Kwonil
Hu, Hui
Eyerly, Bryan
Lu, Zhongyan
Chepngeno, Juliet
Saif, Linda J.
Pathogenicity of 2 Porcine Deltacoronavirus Strains in Gnotobiotic Pigs
title Pathogenicity of 2 Porcine Deltacoronavirus Strains in Gnotobiotic Pigs
title_full Pathogenicity of 2 Porcine Deltacoronavirus Strains in Gnotobiotic Pigs
title_fullStr Pathogenicity of 2 Porcine Deltacoronavirus Strains in Gnotobiotic Pigs
title_full_unstemmed Pathogenicity of 2 Porcine Deltacoronavirus Strains in Gnotobiotic Pigs
title_short Pathogenicity of 2 Porcine Deltacoronavirus Strains in Gnotobiotic Pigs
title_sort pathogenicity of 2 porcine deltacoronavirus strains in gnotobiotic pigs
topic Dispatch
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4378491/
https://www.ncbi.nlm.nih.gov/pubmed/25811229
http://dx.doi.org/10.3201/eid2104.141859
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