Sustained Endothelial Expression of HoxA5 In Vivo Impairs Pathological Angiogenesis And Tumor Progression

HoxA5 is expressed in quiescent endothelial cells (EC), but absent in activated angiogenic EC. To examine the efficacy of targeting HoxA5 therapeutically to quell pathologic or tumor angiogenesis, we generated an inducible, transgenic mouse model of sustained HoxA5 expression in ECs. During patholog...

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Detalles Bibliográficos
Autores principales: Cuevas, Ileana, Layman, Hans, Coussens, Lisa, Boudreau, Nancy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4379087/
https://www.ncbi.nlm.nih.gov/pubmed/25821967
http://dx.doi.org/10.1371/journal.pone.0121720

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4379087/
https://www.ncbi.nlm.nih.gov/pubmed/25821967
http://dx.doi.org/10.1371/journal.pone.0121720

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