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Lung Cancer Incidence Trends by Gender, Race and Histology in the United States, 1973–2010

BACKGROUND: Lung cancer (LC) incidence in the United States (US) continues to decrease but with significant differences by histology, gender and race. Whereas squamous, large and small cell carcinoma rates have been decreasing since the mid-80s, adenocarcinoma rates remain stable in males and contin...

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Autores principales: Meza, Rafael, Meernik, Clare, Jeon, Jihyoun, Cote, Michele L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4379166/
https://www.ncbi.nlm.nih.gov/pubmed/25822850
http://dx.doi.org/10.1371/journal.pone.0121323
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author Meza, Rafael
Meernik, Clare
Jeon, Jihyoun
Cote, Michele L.
author_facet Meza, Rafael
Meernik, Clare
Jeon, Jihyoun
Cote, Michele L.
author_sort Meza, Rafael
collection PubMed
description BACKGROUND: Lung cancer (LC) incidence in the United States (US) continues to decrease but with significant differences by histology, gender and race. Whereas squamous, large and small cell carcinoma rates have been decreasing since the mid-80s, adenocarcinoma rates remain stable in males and continue to increase in females, with large racial disparities. We analyzed LC incidence trends by histology in the US with an emphasis on gender and racial differences. METHODS: LC incidence rates from 1973–2010 were obtained from the SEER cancer registry. Age-adjusted incidence trends of five major histological types by gender and race were evaluated using joinpoint regression. Trends of LC histology and stage distributions from 2005–2010 were analyzed. RESULTS: US LC incidence varies by histology. Squamous, large and small cell carcinoma rates continue to decrease for all gender/race combinations, whereas adenocarcinoma rates remain relatively constant in males and increasing in females. An apparent recent increase in the incidence of squamous cell carcinoma and adenocarcinoma since 2005 can be explained by a concomitant decrease in the number of cases classified as other non-small cell carcinoma. Black males continue to be disproportionally affected by squamous LCs, and blacks continue to be diagnosed with more advanced cancers than whites. CONCLUSIONS: LC incidence by histology continues to change over time. Additional variations are expected as screening becomes disseminated. It is important to continue to monitor LC rates to evaluate the impact of screening on current trends, assess the continuing benefits of tobacco control, and focus efforts on reducing racial disparities.
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spelling pubmed-43791662015-04-09 Lung Cancer Incidence Trends by Gender, Race and Histology in the United States, 1973–2010 Meza, Rafael Meernik, Clare Jeon, Jihyoun Cote, Michele L. PLoS One Research Article BACKGROUND: Lung cancer (LC) incidence in the United States (US) continues to decrease but with significant differences by histology, gender and race. Whereas squamous, large and small cell carcinoma rates have been decreasing since the mid-80s, adenocarcinoma rates remain stable in males and continue to increase in females, with large racial disparities. We analyzed LC incidence trends by histology in the US with an emphasis on gender and racial differences. METHODS: LC incidence rates from 1973–2010 were obtained from the SEER cancer registry. Age-adjusted incidence trends of five major histological types by gender and race were evaluated using joinpoint regression. Trends of LC histology and stage distributions from 2005–2010 were analyzed. RESULTS: US LC incidence varies by histology. Squamous, large and small cell carcinoma rates continue to decrease for all gender/race combinations, whereas adenocarcinoma rates remain relatively constant in males and increasing in females. An apparent recent increase in the incidence of squamous cell carcinoma and adenocarcinoma since 2005 can be explained by a concomitant decrease in the number of cases classified as other non-small cell carcinoma. Black males continue to be disproportionally affected by squamous LCs, and blacks continue to be diagnosed with more advanced cancers than whites. CONCLUSIONS: LC incidence by histology continues to change over time. Additional variations are expected as screening becomes disseminated. It is important to continue to monitor LC rates to evaluate the impact of screening on current trends, assess the continuing benefits of tobacco control, and focus efforts on reducing racial disparities. Public Library of Science 2015-03-30 /pmc/articles/PMC4379166/ /pubmed/25822850 http://dx.doi.org/10.1371/journal.pone.0121323 Text en © 2015 Meza et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Meza, Rafael
Meernik, Clare
Jeon, Jihyoun
Cote, Michele L.
Lung Cancer Incidence Trends by Gender, Race and Histology in the United States, 1973–2010
title Lung Cancer Incidence Trends by Gender, Race and Histology in the United States, 1973–2010
title_full Lung Cancer Incidence Trends by Gender, Race and Histology in the United States, 1973–2010
title_fullStr Lung Cancer Incidence Trends by Gender, Race and Histology in the United States, 1973–2010
title_full_unstemmed Lung Cancer Incidence Trends by Gender, Race and Histology in the United States, 1973–2010
title_short Lung Cancer Incidence Trends by Gender, Race and Histology in the United States, 1973–2010
title_sort lung cancer incidence trends by gender, race and histology in the united states, 1973–2010
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4379166/
https://www.ncbi.nlm.nih.gov/pubmed/25822850
http://dx.doi.org/10.1371/journal.pone.0121323
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