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Immune profile of IgA-dominant diffuse proliferative glomerulonephritis

The diagnosis of IgA-dominant post-infectious glomerulonephritis (PIGN) may be challenging, as it must be differentiated from that of active IgA nephropathy. Predominant clinicopathologic features of IgA-dominant PIGN substantially overlap with those of active IgA nephropathy. Here, we present a cas...

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Autores principales: Wallace, Eric, Maillard, Nicolas, Ueda, Hiroyuki, Hall, Stacy, Fatima, Huma, Novak, Jan, Julian, Bruce A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4379348/
https://www.ncbi.nlm.nih.gov/pubmed/25878780
http://dx.doi.org/10.1093/ckj/sfu090
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author Wallace, Eric
Maillard, Nicolas
Ueda, Hiroyuki
Hall, Stacy
Fatima, Huma
Novak, Jan
Julian, Bruce A.
author_facet Wallace, Eric
Maillard, Nicolas
Ueda, Hiroyuki
Hall, Stacy
Fatima, Huma
Novak, Jan
Julian, Bruce A.
author_sort Wallace, Eric
collection PubMed
description The diagnosis of IgA-dominant post-infectious glomerulonephritis (PIGN) may be challenging, as it must be differentiated from that of active IgA nephropathy. Predominant clinicopathologic features of IgA-dominant PIGN substantially overlap with those of active IgA nephropathy. Here, we present a case of a 67-year-old woman with rapidly rising serum creatinine, proteinuria and severe hypertension. The kidney biopsy findings included some features of IgA-dominant PIGN while others were more consistent with classical IgA nephropathy. We describe this patient's immune profile at the time of acute kidney injury and review the literature regarding differentiation of the two entities.
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spelling pubmed-43793482015-04-15 Immune profile of IgA-dominant diffuse proliferative glomerulonephritis Wallace, Eric Maillard, Nicolas Ueda, Hiroyuki Hall, Stacy Fatima, Huma Novak, Jan Julian, Bruce A. Clin Kidney J Original Contributions The diagnosis of IgA-dominant post-infectious glomerulonephritis (PIGN) may be challenging, as it must be differentiated from that of active IgA nephropathy. Predominant clinicopathologic features of IgA-dominant PIGN substantially overlap with those of active IgA nephropathy. Here, we present a case of a 67-year-old woman with rapidly rising serum creatinine, proteinuria and severe hypertension. The kidney biopsy findings included some features of IgA-dominant PIGN while others were more consistent with classical IgA nephropathy. We describe this patient's immune profile at the time of acute kidney injury and review the literature regarding differentiation of the two entities. Oxford University Press 2014-10 /pmc/articles/PMC4379348/ /pubmed/25878780 http://dx.doi.org/10.1093/ckj/sfu090 Text en © The Author 2014. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved. For permissions, please email: journals.permissions@oup.com. http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Original Contributions
Wallace, Eric
Maillard, Nicolas
Ueda, Hiroyuki
Hall, Stacy
Fatima, Huma
Novak, Jan
Julian, Bruce A.
Immune profile of IgA-dominant diffuse proliferative glomerulonephritis
title Immune profile of IgA-dominant diffuse proliferative glomerulonephritis
title_full Immune profile of IgA-dominant diffuse proliferative glomerulonephritis
title_fullStr Immune profile of IgA-dominant diffuse proliferative glomerulonephritis
title_full_unstemmed Immune profile of IgA-dominant diffuse proliferative glomerulonephritis
title_short Immune profile of IgA-dominant diffuse proliferative glomerulonephritis
title_sort immune profile of iga-dominant diffuse proliferative glomerulonephritis
topic Original Contributions
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4379348/
https://www.ncbi.nlm.nih.gov/pubmed/25878780
http://dx.doi.org/10.1093/ckj/sfu090
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