Cargando…
Platelet-derived growth factors induced lymphangiogenesis: evidence, unanswered questions and upcoming challenges
Crosstalk between angiogenesis and lymphangiogenesis in embryonic development continues during postnatal life and has specific mechanisms involving factors that initiate activation of the intracellular cascade for their specific receptors. Platelet-derived growth factors (PDGFs) and their correspond...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Termedia Publishing House
2015
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4379379/ https://www.ncbi.nlm.nih.gov/pubmed/25861290 http://dx.doi.org/10.5114/aoms.2015.49217 |
_version_ | 1782364176235102208 |
---|---|
author | Jitariu, Andreea Adriana Cimpean, Anca Maria Kundnani, Nilima Rajpal Raica, Marius |
author_facet | Jitariu, Andreea Adriana Cimpean, Anca Maria Kundnani, Nilima Rajpal Raica, Marius |
author_sort | Jitariu, Andreea Adriana |
collection | PubMed |
description | Crosstalk between angiogenesis and lymphangiogenesis in embryonic development continues during postnatal life and has specific mechanisms involving factors that initiate activation of the intracellular cascade for their specific receptors. Platelet-derived growth factors (PDGFs) and their corresponding receptors (PDGFRs) are known as important regulators of blood vessel development in both normal and pathologic angiogenesis. Despite some recent papers which reported a potential role of the PDGF/PDGFR axis in lymphatic spread of tumor cells, a few papers have suggested the potential role of PDGFs in tumor lymphangiogenesis development. The present paper summarizes the potential lymphangiogenic role of the PDGF/PDGFR axis, underlying upcoming challenges in the field. |
format | Online Article Text |
id | pubmed-4379379 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Termedia Publishing House |
record_format | MEDLINE/PubMed |
spelling | pubmed-43793792015-04-08 Platelet-derived growth factors induced lymphangiogenesis: evidence, unanswered questions and upcoming challenges Jitariu, Andreea Adriana Cimpean, Anca Maria Kundnani, Nilima Rajpal Raica, Marius Arch Med Sci State of the Art Paper Crosstalk between angiogenesis and lymphangiogenesis in embryonic development continues during postnatal life and has specific mechanisms involving factors that initiate activation of the intracellular cascade for their specific receptors. Platelet-derived growth factors (PDGFs) and their corresponding receptors (PDGFRs) are known as important regulators of blood vessel development in both normal and pathologic angiogenesis. Despite some recent papers which reported a potential role of the PDGF/PDGFR axis in lymphatic spread of tumor cells, a few papers have suggested the potential role of PDGFs in tumor lymphangiogenesis development. The present paper summarizes the potential lymphangiogenic role of the PDGF/PDGFR axis, underlying upcoming challenges in the field. Termedia Publishing House 2015-03-14 2015-03-16 /pmc/articles/PMC4379379/ /pubmed/25861290 http://dx.doi.org/10.5114/aoms.2015.49217 Text en Copyright © 2015 Termedia & Banach http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Noncommercial 3.0 Unported License, permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | State of the Art Paper Jitariu, Andreea Adriana Cimpean, Anca Maria Kundnani, Nilima Rajpal Raica, Marius Platelet-derived growth factors induced lymphangiogenesis: evidence, unanswered questions and upcoming challenges |
title | Platelet-derived growth factors induced lymphangiogenesis: evidence, unanswered questions and upcoming challenges |
title_full | Platelet-derived growth factors induced lymphangiogenesis: evidence, unanswered questions and upcoming challenges |
title_fullStr | Platelet-derived growth factors induced lymphangiogenesis: evidence, unanswered questions and upcoming challenges |
title_full_unstemmed | Platelet-derived growth factors induced lymphangiogenesis: evidence, unanswered questions and upcoming challenges |
title_short | Platelet-derived growth factors induced lymphangiogenesis: evidence, unanswered questions and upcoming challenges |
title_sort | platelet-derived growth factors induced lymphangiogenesis: evidence, unanswered questions and upcoming challenges |
topic | State of the Art Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4379379/ https://www.ncbi.nlm.nih.gov/pubmed/25861290 http://dx.doi.org/10.5114/aoms.2015.49217 |
work_keys_str_mv | AT jitariuandreeaadriana plateletderivedgrowthfactorsinducedlymphangiogenesisevidenceunansweredquestionsandupcomingchallenges AT cimpeanancamaria plateletderivedgrowthfactorsinducedlymphangiogenesisevidenceunansweredquestionsandupcomingchallenges AT kundnaninilimarajpal plateletderivedgrowthfactorsinducedlymphangiogenesisevidenceunansweredquestionsandupcomingchallenges AT raicamarius plateletderivedgrowthfactorsinducedlymphangiogenesisevidenceunansweredquestionsandupcomingchallenges |