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A Mutational Analysis of Residues in Cholera Toxin A1 Necessary for Interaction with Its Substrate, the Stimulatory G Protein Gsα

Pathogenesis of cholera diarrhea requires cholera toxin (CT)-mediated adenosine diphosphate (ADP)-ribosylation of stimulatory G protein (Gsα) in enterocytes. CT is an AB5 toxin with an inactive CTA1 domain linked via CTA2 to a pentameric receptor-binding B subunit. Allosterically activated CTA1 frag...

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Detalles Bibliográficos
Autores principales:	Jobling, Michael G., Gotow, Lisa F., Yang, Zhijie, Holmes, Randall K.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4379533/ https://www.ncbi.nlm.nih.gov/pubmed/25793724 http://dx.doi.org/10.3390/toxins7030919

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