Generation of CCR5-defective CD34 cells from ZFN-driven stop codon-integrated mesenchymal stem cell clones

BACKGROUNDS: Homozygous 32-bp deletion of the chemokine receptor 5 gene (CCR5) is associated with resistance to human immunodeficiency virus (HIV) infection, while heterozygosity delays HIV progression. Bone marrow transplantation (BMT) from a 32/32 donor has been shown to cure an HIV-infected patie...

Descripción completa

Detalles Bibliográficos
Autores principales: Manotham, Krissanapong, Chattong, Supreecha, Setpakdee, Anant
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4379539/
https://www.ncbi.nlm.nih.gov/pubmed/25890320
http://dx.doi.org/10.1186/s12929-015-0130-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4379539/
https://www.ncbi.nlm.nih.gov/pubmed/25890320
http://dx.doi.org/10.1186/s12929-015-0130-6

Ejemplares similares