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N-acetyl-cysteine, a drug that enhances the endogenous activation of group-II metabotropic glutamate receptors, inhibits nociceptive transmission in humans

BACKGROUND: Emerging research seeking novel analgesic drugs focuses on agents targeting group-II metabotropic glutamate receptors (mGlu2 and mGlu3 receptors). N-Acetylcysteine (NAC) enhances the endogenous activation of mGlu2/3 receptors by activating the glial glutamate:cystine membrane exchanger....

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Detalles Bibliográficos
Autores principales:	Truini, Andrea, Piroso, Serena, Pasquale, Erica, Notartomaso, Serena, Di Stefano, Giulia, Lattanzi, Roberta, Battaglia, Giuseppe, Nicoletti, Ferdinando, Cruccu, Giorgio
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2015
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4379592/ https://www.ncbi.nlm.nih.gov/pubmed/25889381 http://dx.doi.org/10.1186/s12990-015-0009-2

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