Human lung myofibroblast TGFβ1-dependent Smad2/3 signalling is Ca(2+)-dependent and regulated by K(Ca)3.1 K(+) channels

BACKGROUND: Idiopathic pulmonary fibrosis (IPF) is a common and invariably lethal interstitial lung disease with poorly effective therapy. Blockade of the K(+) channel K(Ca)3.1 reduces constitutive α-SMA and Smad2/3 nuclear translocation in IPF-derived human lung myofibroblasts (HLMFs), and inhibits...

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Detalles Bibliográficos
Autores principales: Roach, Katy M, Feghali-Bostwick, Carol, Wulff, Heike, Amrani, Yassine, Bradding, Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4379608/
https://www.ncbi.nlm.nih.gov/pubmed/25829947
http://dx.doi.org/10.1186/s13069-015-0022-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4379608/
https://www.ncbi.nlm.nih.gov/pubmed/25829947
http://dx.doi.org/10.1186/s13069-015-0022-0

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