Cargando…

Human lung myofibroblast TGFβ1-dependent Smad2/3 signalling is Ca(2+)-dependent and regulated by K(Ca)3.1 K(+) channels

BACKGROUND: Idiopathic pulmonary fibrosis (IPF) is a common and invariably lethal interstitial lung disease with poorly effective therapy. Blockade of the K(+) channel K(Ca)3.1 reduces constitutive α-SMA and Smad2/3 nuclear translocation in IPF-derived human lung myofibroblasts (HLMFs), and inhibits...

Descripción completa

Detalles Bibliográficos
Autores principales:	Roach, Katy M, Feghali-Bostwick, Carol, Wulff, Heike, Amrani, Yassine, Bradding, Peter
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2015
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4379608/ https://www.ncbi.nlm.nih.gov/pubmed/25829947 http://dx.doi.org/10.1186/s13069-015-0022-0

Ejemplares similares

Increased constitutive αSMA and Smad2/3 expression in idiopathic pulmonary fibrosis myofibroblasts is K(Ca)3.1-dependent
por: Roach, Katy M, et al.
Publicado: (2014)

The K(+) Channel K(Ca)3.1 as a Novel Target for Idiopathic Pulmonary Fibrosis
por: Roach, Katy Morgan, et al.
Publicado: (2013)

Correction: The K(+) Channel K(Ca)3.1 as a Novel Target for Idiopathic Pulmonary Fibrosis
por: Roach, Katy M, et al.
Publicado: (2014)

Lipoxin A(4) Attenuates Constitutive and TGF-β1–Dependent Profibrotic Activity in Human Lung Myofibroblasts
por: Roach, Katy M., et al.
Publicado: (2015)

K(Ca)3.1 K(+) Channel Expression and Function in Human Bronchial Epithelial Cells
por: Arthur, Greer K., et al.
Publicado: (2015)

K(Ca)3.1 Channel-Blockade Attenuates Airway Pathophysiology in a Sheep Model of Chronic Asthma
por: Van Der Velden, Joanne, et al.
Publicado: (2013)

Functional K(Ca)3.1 K(+) channels are required for human fibrocyte migration
por: Cruse, Glenn, et al.
Publicado: (2011)

Muscle Damage in Dystrophic mdx Mice Is Influenced by the Activity of Ca(2+)-Activated K(Ca)3.1 Channels
por: Morotti, Marta, et al.
Publicado: (2022)

The feeding behaviour of Amyotrophic Lateral Sclerosis mouse models is modulated by the Ca(2+)‐activated K(Ca)3.1 channels
por: Cocozza, Germana, et al.
Publicado: (2021)

New Insights on the Voltage Dependence of the K(Ca)3.1 Channel Block by Internal TBA
por: Banderali, Umberto, et al.
Publicado: (2004)

The Ca(2+)-Activated K(+) Channel KCa3.1 as a Potential New Target for the Prevention of Allograft Vasculopathy
por: Chen, Yi-Je, et al.
Publicado: (2013)

Cancer-Associated Intermediate Conductance Ca(2+)-Activated K(+) Channel K(Ca)3.1
por: Mohr, Corinna J., et al.
Publicado: (2019)

K(Ca)2 and K(Ca)3.1 Channels in the Airways: A New Therapeutic Target
por: Orfali, Razan, et al.
Publicado: (2023)

Engagement of the EP(2) prostanoid receptor closes the K(+) channel K(Ca)3.1 in human lung mast cells and attenuates their migration
por: Duffy, S Mark, et al.
Publicado: (2008)

Orai/CRACM1 and K(Ca)3.1 ion channels interact in the human lung mast cell plasma membrane
por: Duffy, S. Mark, et al.
Publicado: (2015)

Adenosine closes the K(+) channel K(Ca)3.1 in human lung mast cells and inhibits their migration via the adenosine A(2A) receptor
por: Duffy, S Mark, et al.
Publicado: (2007)

K(Ca)3.1 Channels and Glioblastoma: In Vitro Studies
por: Klumpp, Lukas, et al.
Publicado: (2018)

K(Ca)3.1 upregulation preserves endothelium‐dependent vasorelaxation during aging and oxidative stress
por: Choi, Shinkyu, et al.
Publicado: (2016)

Internalization and Transportation of Endothelial Cell Surface K(Ca)2.3 and K(Ca)3.1 in Normal Pregnancy and Preeclampsia
por: Choi, Shinkyu, et al.
Publicado: (2019)

Inhibition of the K(+) Channel K(Ca)3.1 Reduces TGF-β1-Induced Premature Senescence, Myofibroblast Phenotype Transition and Proliferation of Mesangial Cells
por: Fu, Rong-Guo, et al.
Publicado: (2014)

Modulation of Cardiovascular Function in Primary Hypertension in Rat by SKA-31, an Activator of K(Ca)2.x and K(Ca)3.1 Channels
por: Kloza, Monika, et al.
Publicado: (2019)

Novel Phenolic Inhibitors of Small/Intermediate-Conductance Ca(2+)-Activated K(+) Channels, KCa3.1 and KCa2.3
por: Oliván-Viguera, Aida, et al.
Publicado: (2013)

K(Ca)3.1-Dependent Hyperpolarization Enhances Intracellular Ca(2+) Signaling Induced by fMLF in Differentiated U937 Cells
por: Penna, Antonello, et al.
Publicado: (2015)

Pulmonary Hypertension in Wild Type Mice and Animals with Genetic Deficit in K(Ca)2.3 and K(Ca)3.1 Channels
por: Wandall-Frostholm, Christine, et al.
Publicado: (2014)

K(Ca)3.1 Channels Confer Radioresistance to Breast Cancer Cells
por: Mohr, Corinna J., et al.
Publicado: (2019)

The combined activation of K(Ca)3.1 and inhibition of K(v)11.1/hERG1 currents contribute to overcome Cisplatin resistance in colorectal cancer cells
por: Pillozzi, Serena, et al.
Publicado: (2018)

K(Ca)3.1 Channels Promote Cardiac Fibrosis Through Mediating Inflammation and Differentiation of Monocytes Into Myofibroblasts in Angiotensin II–Treated Rats
por: She, Gang, et al.
Publicado: (2018)

K(Ca)3.1-dependent uptake of the cytotoxic DNA-binding dye Hoechst 33258 into cancerous but not healthy cervical cells
por: Bukhari, Maurish, et al.
Publicado: (2020)

Histone Deacetylases Enhance Ca(2+)-Activated K(+) Channel K(Ca)3.1 Expression in Murine Inflammatory CD4(+) T Cells
por: Matsui, Miki, et al.
Publicado: (2018)

Tumoricidal, Temozolomide- and Radiation-Sensitizing Effects of K(Ca)3.1 K(+) Channel Targeting In Vitro Are Dependent on Glioma Cell Line and Stem Cell Fraction
por: Stransky, Nicolai, et al.
Publicado: (2022)

Peptide Lv augments intermediate-conductance calcium-dependent potassium channels (K(Ca)3.1) in endothelial cells to promote angiogenesis
por: Pham, Dylan L., et al.
Publicado: (2022)

Modulation of K(Ca)3.1 Channels by Eicosanoids, Omega-3 Fatty Acids, and Molecular Determinants
por: Kacik, Michael, et al.
Publicado: (2014)

Downregulation of IL-8 and IL-10 by the Activation of Ca(2+)-Activated K(+) Channel K(Ca)3.1 in THP-1-Derived M(2) Macrophages
por: Ohya, Susumu, et al.
Publicado: (2022)

Contradictory Effects of Superoxide and Hydrogen Peroxide on K(Ca)3.1 in Human Endothelial Cells
por: Choi, Shinkyu, et al.
Publicado: (2013)

Functional Roles of the Ca(2+)-activated K(+) Channel, KCa3.1, in Brain Tumors
por: D’Alessandro, Giuseppina, et al.
Publicado: (2018)

Contribution of the Potassium Channels K(V)1.3 and K(Ca)3.1 to Smooth Muscle Cell Proliferation in Growing Collateral Arteries
por: Lasch, Manuel, et al.
Publicado: (2020)

Imaging of K(Ca)3.1 Channels in Tumor Cells with PET and Small‐Molecule Fluorescent Probes
por: Thale, Insa, et al.
Publicado: (2022)

Synthesis and biological evaluation of PET tracers designed for imaging of calcium activated potassium channel 3.1 (K(Ca)3.1) channels in vivo
por: Brömmel, Kathrin, et al.
Publicado: (2021)

Peptide Lv Promotes Trafficking and Membrane Insertion of K(Ca)3.1 through the MEK1–ERK and PI3K–Akt Signaling Pathways
por: Pham, Dylan L., et al.
Publicado: (2023)

Characterization and Chemical Synthesis of Cm39 (α-KTx 4.8): A Scorpion Toxin That Inhibits Voltage-Gated K(+) Channel K(V)1.2 and Small- and Intermediate-Conductance Ca(2+)-Activated K(+) Channels K(Ca)2.2 and K(Ca)3.1
por: Naseem, Muhammad Umair, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_ph2j367r8oom2568k1ei8g8drt