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PGC-1α activity in nigral dopamine neurons determines vulnerability to α-synuclein

INTRODUCTION: Mitochondrial dysfunction and oxidative stress are critical factors in the pathogenesis of age-dependent neurodegenerative diseases. PGC-1α, a master regulator of mitochondrial biogenesis and cellular antioxidant defense, has emerged as a possible therapeutic target for Parkinson’s dis...

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Detalles Bibliográficos
Autores principales:	Ciron, Carine, Zheng, Lu, Bobela, Wojciech, Knott, Graham W, Leone, Teresa C, Kelly, Daniel P, Schneider, Bernard L
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2015
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4379693/ https://www.ncbi.nlm.nih.gov/pubmed/25853296 http://dx.doi.org/10.1186/s40478-015-0200-8

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