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Neural mechanisms of negative reinforcement in children and adolescents with autism spectrum disorders

BACKGROUND: Previous research has found accumulating evidence for atypical reward processing in autism spectrum disorders (ASD), particularly in the context of social rewards. Yet, this line of research has focused largely on positive social reinforcement, while little is known about the processing...

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Autores principales: Damiano, Cara R, Cockrell, Dillon C, Dunlap, Kaitlyn, Hanna, Eleanor K, Miller, Stephanie, Bizzell, Joshua, Kovac, Megan, Turner-Brown, Lauren, Sideris, John, Kinard, Jessica, Dichter, Gabriel S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4379694/
https://www.ncbi.nlm.nih.gov/pubmed/25829969
http://dx.doi.org/10.1186/s11689-015-9107-8
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author Damiano, Cara R
Cockrell, Dillon C
Dunlap, Kaitlyn
Hanna, Eleanor K
Miller, Stephanie
Bizzell, Joshua
Kovac, Megan
Turner-Brown, Lauren
Sideris, John
Kinard, Jessica
Dichter, Gabriel S
author_facet Damiano, Cara R
Cockrell, Dillon C
Dunlap, Kaitlyn
Hanna, Eleanor K
Miller, Stephanie
Bizzell, Joshua
Kovac, Megan
Turner-Brown, Lauren
Sideris, John
Kinard, Jessica
Dichter, Gabriel S
author_sort Damiano, Cara R
collection PubMed
description BACKGROUND: Previous research has found accumulating evidence for atypical reward processing in autism spectrum disorders (ASD), particularly in the context of social rewards. Yet, this line of research has focused largely on positive social reinforcement, while little is known about the processing of negative reinforcement in individuals with ASD. METHODS: The present study examined neural responses to social negative reinforcement (a face displaying negative affect) and non-social negative reinforcement (monetary loss) in children with ASD relative to typically developing children, using functional magnetic resonance imaging (fMRI). RESULTS: We found that children with ASD demonstrated hypoactivation of the right caudate nucleus while anticipating non-social negative reinforcement and hypoactivation of a network of frontostriatal regions (including the nucleus accumbens, caudate nucleus, and putamen) while anticipating social negative reinforcement. In addition, activation of the right caudate nucleus during non-social negative reinforcement was associated with individual differences in social motivation. CONCLUSIONS: These results suggest that atypical responding to negative reinforcement in children with ASD may contribute to social motivational deficits in this population.
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spelling pubmed-43796942015-04-01 Neural mechanisms of negative reinforcement in children and adolescents with autism spectrum disorders Damiano, Cara R Cockrell, Dillon C Dunlap, Kaitlyn Hanna, Eleanor K Miller, Stephanie Bizzell, Joshua Kovac, Megan Turner-Brown, Lauren Sideris, John Kinard, Jessica Dichter, Gabriel S J Neurodev Disord Research BACKGROUND: Previous research has found accumulating evidence for atypical reward processing in autism spectrum disorders (ASD), particularly in the context of social rewards. Yet, this line of research has focused largely on positive social reinforcement, while little is known about the processing of negative reinforcement in individuals with ASD. METHODS: The present study examined neural responses to social negative reinforcement (a face displaying negative affect) and non-social negative reinforcement (monetary loss) in children with ASD relative to typically developing children, using functional magnetic resonance imaging (fMRI). RESULTS: We found that children with ASD demonstrated hypoactivation of the right caudate nucleus while anticipating non-social negative reinforcement and hypoactivation of a network of frontostriatal regions (including the nucleus accumbens, caudate nucleus, and putamen) while anticipating social negative reinforcement. In addition, activation of the right caudate nucleus during non-social negative reinforcement was associated with individual differences in social motivation. CONCLUSIONS: These results suggest that atypical responding to negative reinforcement in children with ASD may contribute to social motivational deficits in this population. BioMed Central 2015-03-25 2015 /pmc/articles/PMC4379694/ /pubmed/25829969 http://dx.doi.org/10.1186/s11689-015-9107-8 Text en © Damiano et al.; licensee BioMed Central. 2015 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research
Damiano, Cara R
Cockrell, Dillon C
Dunlap, Kaitlyn
Hanna, Eleanor K
Miller, Stephanie
Bizzell, Joshua
Kovac, Megan
Turner-Brown, Lauren
Sideris, John
Kinard, Jessica
Dichter, Gabriel S
Neural mechanisms of negative reinforcement in children and adolescents with autism spectrum disorders
title Neural mechanisms of negative reinforcement in children and adolescents with autism spectrum disorders
title_full Neural mechanisms of negative reinforcement in children and adolescents with autism spectrum disorders
title_fullStr Neural mechanisms of negative reinforcement in children and adolescents with autism spectrum disorders
title_full_unstemmed Neural mechanisms of negative reinforcement in children and adolescents with autism spectrum disorders
title_short Neural mechanisms of negative reinforcement in children and adolescents with autism spectrum disorders
title_sort neural mechanisms of negative reinforcement in children and adolescents with autism spectrum disorders
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4379694/
https://www.ncbi.nlm.nih.gov/pubmed/25829969
http://dx.doi.org/10.1186/s11689-015-9107-8
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