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Prognostic effect of matrix metalloproteinase-9 in patients with resected Non small cell lung cancer
BACKGROUND: The role of tumor matrix metalloproteinase-9 (MMP-9) expression in non-small cell lung cancer (NSCLC) remains controversial. In this study, we investigated the prognostic value of tumor MMP-9 expression and other clinicopathologic factors in patients with completely resected NSCLC. METHO...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4379698/ https://www.ncbi.nlm.nih.gov/pubmed/25888323 http://dx.doi.org/10.1186/s13019-015-0248-3 |
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author | Lee, Chang Young Shim, Hyo Sup Lee, Seokkee Lee, Jin Gu Kim, Dae Joon Chung, Kyung Young |
author_facet | Lee, Chang Young Shim, Hyo Sup Lee, Seokkee Lee, Jin Gu Kim, Dae Joon Chung, Kyung Young |
author_sort | Lee, Chang Young |
collection | PubMed |
description | BACKGROUND: The role of tumor matrix metalloproteinase-9 (MMP-9) expression in non-small cell lung cancer (NSCLC) remains controversial. In this study, we investigated the prognostic value of tumor MMP-9 expression and other clinicopathologic factors in patients with completely resected NSCLC. METHODS: This retrospective study included patients who underwent complete resection of pathological stage I–IIIA NSCLC at Severance Hospital, Seoul, Korea, between 1998 and 2009. Tumor samples of 417 patients were stained by immunohistochemistry, and the expression of MMP-9 in tumor cells was evaluated, using the median immunohistochemical score of 10 (range, 0-300) as the cut-off. RESULTS: Tumor MMP-9 expression was observed in 161 (38.6%) of 417 patients. Log-rank analysis showed a significant association of tumor MMP-9 expression with shortened disease-free survival (p = 0.01) but not with overall survival (p = 0.109). Multivariate analysis demonstrated that tumor MMP-9 expression was not an independent prognostic factor of recurrence (p = 0.142) or survival (p = 0.807). However, among patients with adenocarcinoma, tumor MMP-9 expression was associated with relapse (p = 0.003) and poor survival (p = 0.033). Furthermore, tumor MMP-9 expression was an independent prognostic indicator of relapse in patients with adenocarcinoma (p = 0.035). CONCLUSIONS: Among patients with NSCLC, tumor MMP-9 expression was associated with poor outcomes in those with adenocarcinoma, but not in those with squamous cell carcinoma. In addition, MMP-9 expression was identified as an independent predictor of relapse of completely resected lung adenocarcinoma. |
format | Online Article Text |
id | pubmed-4379698 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-43796982015-04-01 Prognostic effect of matrix metalloproteinase-9 in patients with resected Non small cell lung cancer Lee, Chang Young Shim, Hyo Sup Lee, Seokkee Lee, Jin Gu Kim, Dae Joon Chung, Kyung Young J Cardiothorac Surg Research Article BACKGROUND: The role of tumor matrix metalloproteinase-9 (MMP-9) expression in non-small cell lung cancer (NSCLC) remains controversial. In this study, we investigated the prognostic value of tumor MMP-9 expression and other clinicopathologic factors in patients with completely resected NSCLC. METHODS: This retrospective study included patients who underwent complete resection of pathological stage I–IIIA NSCLC at Severance Hospital, Seoul, Korea, between 1998 and 2009. Tumor samples of 417 patients were stained by immunohistochemistry, and the expression of MMP-9 in tumor cells was evaluated, using the median immunohistochemical score of 10 (range, 0-300) as the cut-off. RESULTS: Tumor MMP-9 expression was observed in 161 (38.6%) of 417 patients. Log-rank analysis showed a significant association of tumor MMP-9 expression with shortened disease-free survival (p = 0.01) but not with overall survival (p = 0.109). Multivariate analysis demonstrated that tumor MMP-9 expression was not an independent prognostic factor of recurrence (p = 0.142) or survival (p = 0.807). However, among patients with adenocarcinoma, tumor MMP-9 expression was associated with relapse (p = 0.003) and poor survival (p = 0.033). Furthermore, tumor MMP-9 expression was an independent prognostic indicator of relapse in patients with adenocarcinoma (p = 0.035). CONCLUSIONS: Among patients with NSCLC, tumor MMP-9 expression was associated with poor outcomes in those with adenocarcinoma, but not in those with squamous cell carcinoma. In addition, MMP-9 expression was identified as an independent predictor of relapse of completely resected lung adenocarcinoma. BioMed Central 2015-03-27 /pmc/articles/PMC4379698/ /pubmed/25888323 http://dx.doi.org/10.1186/s13019-015-0248-3 Text en © Lee et al.; licensee BioMed Central. 2015 This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Article Lee, Chang Young Shim, Hyo Sup Lee, Seokkee Lee, Jin Gu Kim, Dae Joon Chung, Kyung Young Prognostic effect of matrix metalloproteinase-9 in patients with resected Non small cell lung cancer |
title | Prognostic effect of matrix metalloproteinase-9 in patients with resected Non small cell lung cancer |
title_full | Prognostic effect of matrix metalloproteinase-9 in patients with resected Non small cell lung cancer |
title_fullStr | Prognostic effect of matrix metalloproteinase-9 in patients with resected Non small cell lung cancer |
title_full_unstemmed | Prognostic effect of matrix metalloproteinase-9 in patients with resected Non small cell lung cancer |
title_short | Prognostic effect of matrix metalloproteinase-9 in patients with resected Non small cell lung cancer |
title_sort | prognostic effect of matrix metalloproteinase-9 in patients with resected non small cell lung cancer |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4379698/ https://www.ncbi.nlm.nih.gov/pubmed/25888323 http://dx.doi.org/10.1186/s13019-015-0248-3 |
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