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Somatic cancer mutations in the MLL3-SET domain alter the catalytic properties of the enzyme
BACKGROUND: Somatic mutations in epigenetic enzymes are frequently found in cancer tissues. The MLL3 H3K4-specific protein lysine monomethyltransferase is an important epigenetic enzyme, and it is among the most recurrently mutated enzymes in cancers. MLL3 mainly introduces H3K4me1 at enhancers. RES...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4379744/ https://www.ncbi.nlm.nih.gov/pubmed/25829971 http://dx.doi.org/10.1186/s13148-015-0075-3 |