Annonaceous acetogenin mimic AA005 induces cancer cell death via apoptosis inducing factor through a caspase-3-independent mechanism

BACKGROUND: Annonaceous acetogenins are a family of natural products with antitumor activities. Annonaceous acetogenin mimic AA005 reportedly inhibits mammalian mitochondrial NADH-ubiquinone reductase (Complex I) and induces gastric cancer cell death. However, the mechanisms underlying its cell-deat...

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Detalles Bibliográficos
Autores principales: Han, Bing, Wang, Tong-Dan, Shen, Shao-Ming, Yu, Yun, Mao, Chan, Yao, Zhu-Jun, Wang, Li-Shun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4379763/
https://www.ncbi.nlm.nih.gov/pubmed/25885900
http://dx.doi.org/10.1186/s12885-015-1133-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4379763/
https://www.ncbi.nlm.nih.gov/pubmed/25885900
http://dx.doi.org/10.1186/s12885-015-1133-0

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