A method to control phosphoinositides and to analyze PTEN function in living cells using voltage sensitive phosphatases

Voltage sensitive phosphatases (VSPs), including engineered voltage sensitive PTEN, are excellent tools to rapidly and reversibly alter the phosphoinositide (PI) content of the plasma membrane in vivo and study the tumor suppressor PTEN. However, widespread adoption of these tools is hampered by the...

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Detalles Bibliográficos
Autores principales: Mavrantoni, Angeliki, Thallmair, Veronika, Leitner, Michael G., Schreiber, Daniela N., Oliver, Dominik, Halaszovich, Christian R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2015
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4379879/
https://www.ncbi.nlm.nih.gov/pubmed/25873899
http://dx.doi.org/10.3389/fphar.2015.00068

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