Cargando…

Nigral proteasome inhibition in mice leads to motor and non-motor deficits and increased expression of Ser129 phosphorylated α-synuclein

Parkinson's disease is a neurodegenerative disorder characterized by motor and non-motor disturbances. Various pathogenic pathways drive disease progression including oxidative stress, mitochondrial dysfunction, α-synuclein aggregation and impairment of protein degradation systems. Dysfunction...

Descripción completa

Detalles Bibliográficos
Autores principales:	Bentea, Eduard, Van der Perren, Anke, Van Liefferinge, Joeri, El Arfani, Anissa, Albertini, Giulia, Demuyser, Thomas, Merckx, Ellen, Michotte, Yvette, Smolders, Ilse, Baekelandt, Veerle, Massie, Ann
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2015
Materias:	Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4379937/ https://www.ncbi.nlm.nih.gov/pubmed/25873870 http://dx.doi.org/10.3389/fnbeh.2015.00068

Ejemplares similares

Caloric Restriction Protects against Lactacystin-Induced Degeneration of Dopamine Neurons Independent of the Ghrelin Receptor
por: Coppens, Jessica, et al.
Publicado: (2017)

Absence of system x(c)(−) on immune cells invading the central nervous system alleviates experimental autoimmune encephalitis
por: Merckx, Ellen, et al.
Publicado: (2017)

Chronic nigral neuromodulation aggravates behavioral deficits and synaptic changes in an α-synuclein based rat model for Parkinson’s disease
por: Torre-Muruzabal, Teresa, et al.
Publicado: (2019)

Nigral overexpression of alpha-synuclein in the absence of parkin enhances alpha-synuclein phosphorylation but does not modulate dopaminergic neurodegeneration
por: Van Rompuy, Anne-Sophie, et al.
Publicado: (2015)

Are vesicular neurotransmitter transporters potential treatment targets for temporal lobe epilepsy?
por: Van Liefferinge, Joeri, et al.
Publicado: (2013)

Nigral neuropathology of Parkinson’s motor subtypes coincide with circuitopathies: a scoping review
por: Boonstra, Jackson Tyler, et al.
Publicado: (2022)

Disentangling nigral and putaminal contribution to motor impairment and levodopa response in Parkinson’s disease
por: Schröter, Nils, et al.
Publicado: (2022)

Oxidative Stress in Genetic Mouse Models of Parkinson's Disease
por: Varçin, Mustafa, et al.
Publicado: (2012)

Subthalamic nucleus stimulation attenuates motor seizures via modulating the nigral orexin pathway
por: Xue, Tao, et al.
Publicado: (2023)

Nigral stimulation for resistant axial motor impairment in Parkinson’s disease? A randomized controlled trial
por: Weiss, Daniel, et al.
Publicado: (2013)

Inhibition of Nigral Microglial Activation Reduces Age-Related Loss of Dopaminergic Neurons and Motor Deficits
por: Wang, Tzu-Feng, et al.
Publicado: (2022)

The Proteasome Inhibition Model of Parkinson’s Disease
por: Bentea, Eduard, et al.
Publicado: (2017)

Linking Neuroinflammation and Neurodegeneration in Parkinson's Disease
por: Gelders, Géraldine, et al.
Publicado: (2018)

VMAT2-Deficient Mice Display Nigral and Extranigral Pathology and Motor and Nonmotor Symptoms of Parkinson's Disease
por: Taylor, Tonya N., et al.
Publicado: (2011)

Asymmetrical nigral iron accumulation in Parkinson’s disease with motor asymmetry: an explorative, longitudinal and test-retest study
por: Guan, Xiaojun, et al.
Publicado: (2020)

Motor cortico-nigral and cortico-entopeduncular information transmission and its modulation by buspirone in control and after dopaminergic denervation
por: Vegas-Suárez, Sergio, et al.
Publicado: (2022)

Optogenetic activation of nigral inhibitory inputs to motor thalamus in the mouse reveals classic inhibition with little potential for rebound activation
por: Edgerton, Jeremy R., et al.
Publicado: (2014)

Anti-oxidant polydatin (piceid) protects against substantia nigral motor degeneration in multiple rodent models of Parkinson’s disease
por: Chen, Yupin, et al.
Publicado: (2015)

Aging Reveals a Role for Nigral Tyrosine Hydroxylase ser31 Phosphorylation in Locomotor Activity Generation
por: Salvatore, Michael F., et al.
Publicado: (2009)

Critical Evaluation of Acetylcholine Determination in Rat Brain Microdialysates using Ion-Pair Liquid Chromatography with Amperometric Detection
por: De Bundel, Dimitri, et al.
Publicado: (2008)

Toll-like receptor 4 stimulation with monophosphoryl lipid A ameliorates motor deficits and nigral neurodegeneration triggered by extraneuronal α-synucleinopathy
por: Venezia, Serena, et al.
Publicado: (2017)

Motor Coordination Disorders Evaluated through the Grid Test and Changes in the Nigral Nrf2 mRNA Expression in Rats with Pedunculopontine Lesion
por: Blanco-Lezcano, Lisette, et al.
Publicado: (2020)

Identifying a glucose metabolic brain pattern in an adeno-associated viral vector based rat model for Parkinson’s disease using (18)F-FDG PET imaging
por: Devrome, Martijn, et al.
Publicado: (2019)

Mechanisms underlying extensive Ser129-phosphorylation in α-synuclein aggregates
por: Arawaka, Shigeki, et al.
Publicado: (2017)

Ketamine Does Not Exert Protective Properties on Dopaminergic Neurons in the Lactacystin Mouse Model of Parkinson’s Disease
por: Deneyer, Lauren, et al.
Publicado: (2018)

Peripheral Inflammation Regulates CNS Immune Surveillance Through the Recruitment of Inflammatory Monocytes Upon Systemic α-Synuclein Administration
por: Peralta Ramos, Javier María, et al.
Publicado: (2019)

Nigral iron deposition in common tremor disorders
por: Homayoon, Nina, et al.
Publicado: (2018)

Discovery of nigral dopaminergic neurogenesis in adult mice
por: Morrison, Brad E.
Publicado: (2016)

Height and nigral neuron density in Parkinson’s disease
por: Saari, Laura, et al.
Publicado: (2022)

Plasma pS129-α-Synuclein Is a Surrogate Biofluid Marker of Motor Severity and Progression in Parkinson’s Disease
por: Lin, Chin-Hsien, et al.
Publicado: (2019)

Elbow Extension Predicts Motor Impairment and Performance after Stroke
por: Massie, Crystal L., et al.
Publicado: (2011)

Modelling Ser129 Phosphorylation Inhibits Membrane Binding of Pore-Forming Alpha-Synuclein Oligomers
por: Nübling, Georg Sebastian, et al.
Publicado: (2014)

Increased P2X7 Receptor Binding Is Associated With Neuroinflammation in Acute but Not Chronic Rodent Models for Parkinson’s Disease
por: Crabbé, Melissa, et al.
Publicado: (2019)

Aged xCT-Deficient Mice Are Less Susceptible for Lactacystin-, but Not 1-Methyl-4-Phenyl-1,2,3,6- Tetrahydropyridine-, Induced Degeneration of the Nigrostriatal Pathway
por: Bentea, Eduard, et al.
Publicado: (2021)

Sensitive western blotting for detection of endogenous Ser129-phosphorylated α-synuclein in intracellular and extracellular spaces
por: Sasaki, Asuka, et al.
Publicado: (2015)

Development of a Novel Electrochemiluminescence ELISA for Quantification of α-Synuclein Phosphorylated at Ser(129) in Biological Samples
por: Dutta, Suman, et al.
Publicado: (2023)

rAAV2/7 vector-mediated overexpression of alpha-synuclein in mouse substantia nigra induces protein aggregation and progressive dose-dependent neurodegeneration
por: Oliveras-Salvá, Marusela, et al.
Publicado: (2013)

Impact of age and vector construct on striatal and nigral transgene expression
por: Polinski, Nicole K, et al.
Publicado: (2016)

Effects of Subthalamic and Nigral Stimulation on Gait Kinematics in Parkinson’s Disease
por: Scholten, Marlieke, et al.
Publicado: (2017)

Reversing Parkinson Disease Model with in situ Converted Nigral Neurons
por: Qian, Hao, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_niff3a8ndvfnqo658nnrf90s0j