5-hydroxymethylcytosine marks promoters in colon that resist DNA hypermethylation in cancer

BACKGROUND: The discovery of cytosine hydroxymethylation (5hmC) as a mechanism that potentially controls DNA methylation changes typical of neoplasia prompted us to investigate its behaviour in colon cancer. 5hmC is globally reduced in proliferating cells such as colon tumours and the gut crypt prog...

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Detalles Bibliográficos
Autores principales: Uribe-Lewis, Santiago, Stark, Rory, Carroll, Thomas, Dunning, Mark J, Bachman, Martin, Ito, Yoko, Stojic, Lovorka, Halim, Silvia, Vowler, Sarah L, Lynch, Andy G, Delatte, Benjamin, de Bony, Eric J, Colin, Laurence, Defrance, Matthieu, Krueger, Felix, Silva, Ana-Luisa, ten Hoopen, Rogier, Ibrahim, Ashraf EK, Fuks, François, Murrell, Adele
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4380107/
https://www.ncbi.nlm.nih.gov/pubmed/25853800
http://dx.doi.org/10.1186/s13059-015-0605-5

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