Thiasporines A–C, Thiazine and Thiazole Derivatives from a Marine-Derived Actinomycetospora chlora

[Image: see text] Thiasporine A (1), the first natural product with a 5-hydroxy-4H-1,3-thiazin-4-one moiety, along with two new thiazole derivatives, thiasporines B and C (2 and 3), were isolated from the marine-derived Actinomycetospora chlora SNC-032. The structures of 1–3 were established on the...

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Autores principales: Fu, Peng, MacMillan, John B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society and American Society of Pharmacognosy 2015
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4380196/
https://www.ncbi.nlm.nih.gov/pubmed/25584783
http://dx.doi.org/10.1021/np500929z
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author Fu, Peng
MacMillan, John B.
author_facet Fu, Peng
MacMillan, John B.
author_sort Fu, Peng
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description [Image: see text] Thiasporine A (1), the first natural product with a 5-hydroxy-4H-1,3-thiazin-4-one moiety, along with two new thiazole derivatives, thiasporines B and C (2 and 3), were isolated from the marine-derived Actinomycetospora chlora SNC-032. The structures of 1–3 were established on the basis of comprehensive spectroscopic analysis and chemical methods. Thiasporine A showed cytotoxicity against the non-small-cell lung cancer cell line H2122 with an IC(50) value of 5.4 μM.
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spelling pubmed-43801962016-01-13 Thiasporines A–C, Thiazine and Thiazole Derivatives from a Marine-Derived Actinomycetospora chlora Fu, Peng MacMillan, John B. J Nat Prod [Image: see text] Thiasporine A (1), the first natural product with a 5-hydroxy-4H-1,3-thiazin-4-one moiety, along with two new thiazole derivatives, thiasporines B and C (2 and 3), were isolated from the marine-derived Actinomycetospora chlora SNC-032. The structures of 1–3 were established on the basis of comprehensive spectroscopic analysis and chemical methods. Thiasporine A showed cytotoxicity against the non-small-cell lung cancer cell line H2122 with an IC(50) value of 5.4 μM. American Chemical Society and American Society of Pharmacognosy 2015-01-13 2015-03-27 /pmc/articles/PMC4380196/ /pubmed/25584783 http://dx.doi.org/10.1021/np500929z Text en Copyright © 2015 American Chemical Society and American Society of Pharmacognosy This is an open access article published under an ACS AuthorChoice License (http://pubs.acs.org/page/policy/authorchoice_termsofuse.html) , which permits copying and redistribution of the article or any adaptations for non-commercial purposes.
spellingShingle Fu, Peng
MacMillan, John B.
Thiasporines A–C, Thiazine and Thiazole Derivatives from a Marine-Derived Actinomycetospora chlora
title Thiasporines A–C, Thiazine and Thiazole Derivatives from a Marine-Derived Actinomycetospora chlora
title_full Thiasporines A–C, Thiazine and Thiazole Derivatives from a Marine-Derived Actinomycetospora chlora
title_fullStr Thiasporines A–C, Thiazine and Thiazole Derivatives from a Marine-Derived Actinomycetospora chlora
title_full_unstemmed Thiasporines A–C, Thiazine and Thiazole Derivatives from a Marine-Derived Actinomycetospora chlora
title_short Thiasporines A–C, Thiazine and Thiazole Derivatives from a Marine-Derived Actinomycetospora chlora
title_sort thiasporines a–c, thiazine and thiazole derivatives from a marine-derived actinomycetospora chlora
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4380196/
https://www.ncbi.nlm.nih.gov/pubmed/25584783
http://dx.doi.org/10.1021/np500929z
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