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Two distinct effects of PIP(2) underlie auxiliary subunit-dependent modulation of Slo1 BK channels

Phosphatidylinositol 4,5-bisphosphate (PIP(2)) plays a critical role in modulating the function of numerous ion channels, including large-conductance Ca(2+)- and voltage-dependent K(+) (BK, Slo1) channels. Slo1 BK channel complexes include four pore-forming Slo1 (α) subunits as well as various regul...

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Detalles Bibliográficos
Autores principales:	Tian, Yutao, Ullrich, Florian, Xu, Rong, Heinemann, Stefan H., Hou, Shangwei, Hoshi, Toshinori
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2015
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4380209/ https://www.ncbi.nlm.nih.gov/pubmed/25825171 http://dx.doi.org/10.1085/jgp.201511363

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