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Cysteine accessibility probes timing and extent of NBD separation along the dimer interface in gating CFTR channels
Cystic fibrosis transmembrane conductance regulator (CFTR) channel opening and closing are driven by cycles of adenosine triphosphate (ATP) binding–induced formation and hydrolysis-triggered disruption of a heterodimer of its cytoplasmic nucleotide-binding domains (NBDs). Although both composite sit...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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The Rockefeller University Press
2015
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4380215/ https://www.ncbi.nlm.nih.gov/pubmed/25825169 http://dx.doi.org/10.1085/jgp.201411347 |