Selective Inhibition of p300 HAT Blocks Cell Cycle Progression, Induces Cellular Senescence and Inhibits the DNA Damage Response in Melanoma Cells

Epigenetic events, including covalent post-translational modifications of histones, have been demonstrated to play critical roles in tumor development and progression. The transcriptional coactivator p300/CBP possesses both histone acetyltransferase (HAT) activity as well as scaffolding properties t...

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Detalles Bibliográficos
Autores principales: Yan, Gai, Eller, Mark S., Elm, Courtney, Larocca, Cecilia A., Ryu, Byungwoo, Panova, Izabela P., Dancy, Beverley M., Bowers, Erin M., Meyers, David, Lareau, Lisa, Cole, Philip A., Taverna, Sean D., Alani, Rhoda M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4380234/
https://www.ncbi.nlm.nih.gov/pubmed/23698071
http://dx.doi.org/10.1038/jid.2013.187

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