A Mouse Model of Human Primitive Neuroectodermal Tumors Resulting from Microenvironmentally-Driven Malignant Transformation of Orthotopically Transplanted Radial Glial Cells

There is growing evidence and a consensus in the field that most pediatric brain tumors originate from stem cells, of which radial glial cells constitute a subtype. Here we show that orthotopic transplantation of human radial glial (RG) cells to the subventricular zone of the 3rd ventricle - but not...

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Detalles Bibliográficos
Autores principales: Malchenko, Sergey, Sredni, Simone Treiger, Hashimoto, Hitoshi, Kasai, Atsushi, Nagayasu, Kazuki, Xie, Jianping, Margaryan, Naira V., Seiriki, Kaoru, Lulla, Rishi R., Seftor, Richard E. B., Pachman, Lauren M., Meltzer, Herbert Y., Hendrix, Mary J. C., Soares, Marcelo B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4380339/
https://www.ncbi.nlm.nih.gov/pubmed/25826270
http://dx.doi.org/10.1371/journal.pone.0121707

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