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Excess Body Mass Index- and Waist Circumference-Years and Incident Cardiovascular Disease: The CARDIA Study
OBJECTIVE: Determine the influence of the total cumulative exposure to excess overall and abdominal adiposity on the incidence of cardiovascular disease (CVD). DESIGN: Prospective study of 4,061 white and black adults without CVD at baseline in 1985-86 (age 18-30 years) from the multicenter, communi...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2015
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4380633/ https://www.ncbi.nlm.nih.gov/pubmed/25755157 http://dx.doi.org/10.1002/oby.21023 |
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author | Reis, Jared P. Allen, Norrina Gunderson, Erica P. Lee, Joyce M. Lewis, Cora E. Loria, Catherine M. Powell-Wiley, Tiffany M. Rana, Jamal S. Sidney, Stephen Wei, Gina Yano, Yuichiro Liu, Kiang |
author_facet | Reis, Jared P. Allen, Norrina Gunderson, Erica P. Lee, Joyce M. Lewis, Cora E. Loria, Catherine M. Powell-Wiley, Tiffany M. Rana, Jamal S. Sidney, Stephen Wei, Gina Yano, Yuichiro Liu, Kiang |
author_sort | Reis, Jared P. |
collection | PubMed |
description | OBJECTIVE: Determine the influence of the total cumulative exposure to excess overall and abdominal adiposity on the incidence of cardiovascular disease (CVD). DESIGN: Prospective study of 4,061 white and black adults without CVD at baseline in 1985-86 (age 18-30 years) from the multicenter, community-based CARDIA study. Time-varying excess body mass index (BMI) and waist circumference (WC)-years were calculated as products of the degree and duration of excess overall (BMI ≥25 kg/m(2)) and abdominal adiposity [WC >94 cm (men) and >80 cm (women)], respectively, collected at up to eight examinations. RESULTS: During a median of 24.8 years, there were 125 incident CVD, 62 coronary heart disease (CHD), and 33 heart failure (HF) events. Adjusted hazard ratios for CVD, CHD, and HF for each additional 50 excess BMI-years were 1.20 (1.08, 1.34), 1.25 (1.07, 1.46), and 1.45 (1.23, 1.72), respectively. For each 50 excess WC-years, these hazard ratios were 1.10 (1.04, 1.18), 1.13 (1.03, 1.24), and 1.22 (1.11, 1.34), respectively. Akaike information criterion values were lowest in models containing time-varying excess BMI- or WC-years than those including time-varying BMI or WC only. CONCLUSIONS: Excess BMI- and WC-years are predictors of the risk of CVD and may provide a better indicator of the cumulative exposure to excess adiposity than BMI or WC only. |
format | Online Article Text |
id | pubmed-4380633 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
record_format | MEDLINE/PubMed |
spelling | pubmed-43806332016-04-01 Excess Body Mass Index- and Waist Circumference-Years and Incident Cardiovascular Disease: The CARDIA Study Reis, Jared P. Allen, Norrina Gunderson, Erica P. Lee, Joyce M. Lewis, Cora E. Loria, Catherine M. Powell-Wiley, Tiffany M. Rana, Jamal S. Sidney, Stephen Wei, Gina Yano, Yuichiro Liu, Kiang Obesity (Silver Spring) Article OBJECTIVE: Determine the influence of the total cumulative exposure to excess overall and abdominal adiposity on the incidence of cardiovascular disease (CVD). DESIGN: Prospective study of 4,061 white and black adults without CVD at baseline in 1985-86 (age 18-30 years) from the multicenter, community-based CARDIA study. Time-varying excess body mass index (BMI) and waist circumference (WC)-years were calculated as products of the degree and duration of excess overall (BMI ≥25 kg/m(2)) and abdominal adiposity [WC >94 cm (men) and >80 cm (women)], respectively, collected at up to eight examinations. RESULTS: During a median of 24.8 years, there were 125 incident CVD, 62 coronary heart disease (CHD), and 33 heart failure (HF) events. Adjusted hazard ratios for CVD, CHD, and HF for each additional 50 excess BMI-years were 1.20 (1.08, 1.34), 1.25 (1.07, 1.46), and 1.45 (1.23, 1.72), respectively. For each 50 excess WC-years, these hazard ratios were 1.10 (1.04, 1.18), 1.13 (1.03, 1.24), and 1.22 (1.11, 1.34), respectively. Akaike information criterion values were lowest in models containing time-varying excess BMI- or WC-years than those including time-varying BMI or WC only. CONCLUSIONS: Excess BMI- and WC-years are predictors of the risk of CVD and may provide a better indicator of the cumulative exposure to excess adiposity than BMI or WC only. 2015-03-09 2015-04 /pmc/articles/PMC4380633/ /pubmed/25755157 http://dx.doi.org/10.1002/oby.21023 Text en http://www.nature.com/authors/editorial_policies/license.html#terms Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:http://www.nature.com/authors/editorial_policies/license.html#terms |
spellingShingle | Article Reis, Jared P. Allen, Norrina Gunderson, Erica P. Lee, Joyce M. Lewis, Cora E. Loria, Catherine M. Powell-Wiley, Tiffany M. Rana, Jamal S. Sidney, Stephen Wei, Gina Yano, Yuichiro Liu, Kiang Excess Body Mass Index- and Waist Circumference-Years and Incident Cardiovascular Disease: The CARDIA Study |
title | Excess Body Mass Index- and Waist Circumference-Years and Incident Cardiovascular Disease: The CARDIA Study |
title_full | Excess Body Mass Index- and Waist Circumference-Years and Incident Cardiovascular Disease: The CARDIA Study |
title_fullStr | Excess Body Mass Index- and Waist Circumference-Years and Incident Cardiovascular Disease: The CARDIA Study |
title_full_unstemmed | Excess Body Mass Index- and Waist Circumference-Years and Incident Cardiovascular Disease: The CARDIA Study |
title_short | Excess Body Mass Index- and Waist Circumference-Years and Incident Cardiovascular Disease: The CARDIA Study |
title_sort | excess body mass index- and waist circumference-years and incident cardiovascular disease: the cardia study |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4380633/ https://www.ncbi.nlm.nih.gov/pubmed/25755157 http://dx.doi.org/10.1002/oby.21023 |
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