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Role of pleiotropy during adaptation of TEM-1 β-lactamase to two novel antibiotics

Pleiotropy is a key feature of the genotype–phenotype map, and its form and extent have many evolutionary implications, including for the dynamics of adaptation and the evolution of specialization. Similarly, pleiotropic effects of antibiotic resistance mutations may affect the evolution of antibiot...

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Detalles Bibliográficos
Autores principales:	Schenk, Martijn F, Witte, Sariette, Salverda, Merijn L M, Koopmanschap, Bertha, Krug, Joachim, de Visser, J Arjan G M
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Blackwell Publishing Ltd 2015
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4380919/ https://www.ncbi.nlm.nih.gov/pubmed/25861383 http://dx.doi.org/10.1111/eva.12200

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