Kinase-two-hybrid: towards the conditional interactome

The dynamics of the protein–protein interaction network and how it responds to biological perturbations remain difficult to assay by most traditional techniques. A novel kinase-dependent yeast two-hybrid framework by Stelzl and colleagues (Grossmann et al, 2015) provides a new prism to study how tyr...

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Detalles Bibliográficos
Autores principales: Ochoa, David, Beltrao, Pedro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BlackWell Publishing Ltd 2015
Materias:
News & Views
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4380932/
https://www.ncbi.nlm.nih.gov/pubmed/25814556
http://dx.doi.org/10.15252/msb.20156107
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author Ochoa, David
Beltrao, Pedro
author_facet Ochoa, David
Beltrao, Pedro
author_sort Ochoa, David
collection PubMed
description The dynamics of the protein–protein interaction network and how it responds to biological perturbations remain difficult to assay by most traditional techniques. A novel kinase-dependent yeast two-hybrid framework by Stelzl and colleagues (Grossmann et al, 2015) provides a new prism to study how tyrosine phosphorylation regulates the changes in the interactome under varying conditions.
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spelling pubmed-43809322015-04-03 Kinase-two-hybrid: towards the conditional interactome Ochoa, David Beltrao, Pedro Mol Syst Biol News & Views The dynamics of the protein–protein interaction network and how it responds to biological perturbations remain difficult to assay by most traditional techniques. A novel kinase-dependent yeast two-hybrid framework by Stelzl and colleagues (Grossmann et al, 2015) provides a new prism to study how tyrosine phosphorylation regulates the changes in the interactome under varying conditions. BlackWell Publishing Ltd 2015-03-26 /pmc/articles/PMC4380932/ /pubmed/25814556 http://dx.doi.org/10.15252/msb.20156107 Text en © 2015 The Authors. Published under the terms of the CC BY 4.0 license http://creativecommons.org/licenses/by/4.0/ This is an open access article under the terms of the Creative Commons Attribution 4.0 License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle News & Views
Ochoa, David
Beltrao, Pedro
Kinase-two-hybrid: towards the conditional interactome
title Kinase-two-hybrid: towards the conditional interactome
title_full Kinase-two-hybrid: towards the conditional interactome
title_fullStr Kinase-two-hybrid: towards the conditional interactome
title_full_unstemmed Kinase-two-hybrid: towards the conditional interactome
title_short Kinase-two-hybrid: towards the conditional interactome
title_sort kinase-two-hybrid: towards the conditional interactome
topic News & Views
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4380932/
https://www.ncbi.nlm.nih.gov/pubmed/25814556
http://dx.doi.org/10.15252/msb.20156107
work_keys_str_mv AT ochoadavid kinasetwohybridtowardstheconditionalinteractome
AT beltraopedro kinasetwohybridtowardstheconditionalinteractome

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