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Design, Synthesis, and Biological Evaluation of Tetra-Substituted Thiophenes as Inhibitors of p38α MAPK

p38α mitogen-activated protein kinase (MAPK) plays a role in several cellular processes and consequently has been a therapeutic target in inflammatory diseases, cancer, and cardiovascular disease. A number of known p38α MAPK inhibitors contain vicinal 4-fluorophenyl/4-pyridyl rings connected to eith...

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Detalles Bibliográficos
Autores principales:	Vinh, Natalie B, Devine, Shane M, Munoz, Lenka, Ryan, Renae M, Wang, Bing H, Krum, Henry, Chalmers, David K, Simpson, Jamie S, Scammells, Peter J
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BlackWell Publishing Ltd 2015
Materias:	Full Papers
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4380954/ https://www.ncbi.nlm.nih.gov/pubmed/25861571 http://dx.doi.org/10.1002/open.201402076

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