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Brr2 plays a role in spliceosomal activation in addition to U4/U6 unwinding

Brr2 is a DExD/H-box RNA helicase that is responsible for U4/U6 unwinding, a critical step in spliceosomal activation. Brr2 is a large protein (∼250 kD) that consists of an N-terminal domain (∼500 residues) with unknown function and two Hel308-like modules that are responsible for RNA unwinding. Her...

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Detalles Bibliográficos
Autores principales:	Zhang, Lingdi, Li, Xueni, Hill, Ryan C., Qiu, Yan, Zhang, Wenzheng, Hansen, Kirk C., Zhao, Rui
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2015
Materias:	RNA
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4381053/ https://www.ncbi.nlm.nih.gov/pubmed/25670679 http://dx.doi.org/10.1093/nar/gkv062

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