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A novel role for the mono-ADP-ribosyltransferase PARP14/ARTD8 in promoting homologous recombination and protecting against replication stress

Genomic instability, a major hallmark of cancer cells, is caused by incorrect or ineffective DNA repair. Many DNA repair mechanisms cooperate in cells to fight DNA damage, and are generally regulated by post-translational modification of key factors. Poly-ADP-ribosylation, catalyzed by PARP1, is a p...

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Detalles Bibliográficos
Autores principales:	Nicolae, Claudia M., Aho, Erin R., Choe, Katherine N., Constantin, Daniel, Hu, He-Juan, Lee, Deokjae, Myung, Kyungjae, Moldovan, George-Lucian
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2015
Materias:	Genome Integrity, Repair and Replication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4381061/ https://www.ncbi.nlm.nih.gov/pubmed/25753673 http://dx.doi.org/10.1093/nar/gkv147

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