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The Place of Targeted Agents in the Treatment of Elderly Patients with Metastatic Colorectal Cancer
Despite the high prevalence of colorectal cancer in a continuously aging population and the substantial advances in the treatment of metastatic disease during the past decade, the treatment of elderly patients with advanced, unresectable or metastatic colorectal cancer is a clearly unmet need. Since...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4381267/ https://www.ncbi.nlm.nih.gov/pubmed/25782007 http://dx.doi.org/10.3390/cancers7010439 |
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author | Matikas, Alexios Asimakopoulou, Natalia Georgoulias, Vassilis Souglakos, John |
author_facet | Matikas, Alexios Asimakopoulou, Natalia Georgoulias, Vassilis Souglakos, John |
author_sort | Matikas, Alexios |
collection | PubMed |
description | Despite the high prevalence of colorectal cancer in a continuously aging population and the substantial advances in the treatment of metastatic disease during the past decade, the treatment of elderly patients with advanced, unresectable or metastatic colorectal cancer is a clearly unmet need. Since older patients are under-represented or even excluded from randomized trials, the evidence that oncologists use as guidance is weak. However, small prospective studies, pooled analyses and observational studies show that combination approaches are safe, efficacious and feasible in the geriatric population with metastatic colorectal cancer. The use of biologic agents targeting angiogenesis and the epidermal growth factor receptor, which have been shown to clearly improve outcomes in multiple prospective trials in patients with advanced colorectal cancer, is a vital component of the aforementioned combination approaches. Herein, we review all available data concerning the management of elderly patients with these agents and underscore the differences between this age subgroup and younger patients. |
format | Online Article Text |
id | pubmed-4381267 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-43812672015-05-04 The Place of Targeted Agents in the Treatment of Elderly Patients with Metastatic Colorectal Cancer Matikas, Alexios Asimakopoulou, Natalia Georgoulias, Vassilis Souglakos, John Cancers (Basel) Review Despite the high prevalence of colorectal cancer in a continuously aging population and the substantial advances in the treatment of metastatic disease during the past decade, the treatment of elderly patients with advanced, unresectable or metastatic colorectal cancer is a clearly unmet need. Since older patients are under-represented or even excluded from randomized trials, the evidence that oncologists use as guidance is weak. However, small prospective studies, pooled analyses and observational studies show that combination approaches are safe, efficacious and feasible in the geriatric population with metastatic colorectal cancer. The use of biologic agents targeting angiogenesis and the epidermal growth factor receptor, which have been shown to clearly improve outcomes in multiple prospective trials in patients with advanced colorectal cancer, is a vital component of the aforementioned combination approaches. Herein, we review all available data concerning the management of elderly patients with these agents and underscore the differences between this age subgroup and younger patients. MDPI 2015-03-13 /pmc/articles/PMC4381267/ /pubmed/25782007 http://dx.doi.org/10.3390/cancers7010439 Text en © 2015 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Matikas, Alexios Asimakopoulou, Natalia Georgoulias, Vassilis Souglakos, John The Place of Targeted Agents in the Treatment of Elderly Patients with Metastatic Colorectal Cancer |
title | The Place of Targeted Agents in the Treatment of Elderly Patients with Metastatic Colorectal Cancer |
title_full | The Place of Targeted Agents in the Treatment of Elderly Patients with Metastatic Colorectal Cancer |
title_fullStr | The Place of Targeted Agents in the Treatment of Elderly Patients with Metastatic Colorectal Cancer |
title_full_unstemmed | The Place of Targeted Agents in the Treatment of Elderly Patients with Metastatic Colorectal Cancer |
title_short | The Place of Targeted Agents in the Treatment of Elderly Patients with Metastatic Colorectal Cancer |
title_sort | place of targeted agents in the treatment of elderly patients with metastatic colorectal cancer |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4381267/ https://www.ncbi.nlm.nih.gov/pubmed/25782007 http://dx.doi.org/10.3390/cancers7010439 |
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