Cargando…

Visceral fat obesity is highly associated with primary gout in a metabolically obese but normal weighted population: a case control study

INTRODUCTION: Gout is a chronic inflammatory disease the development of which is associated with obesity-induced metabolic abnormalities. However, a substantial number of non-obese patients (body mass index [BMI] <25 kg/m(2)) also develop gout in Korea. It was suggested that accumulation of visce...

Descripción completa

Detalles Bibliográficos
Autores principales: Lee, Jennifer, Lee, Ji-Yeon, Lee, Jae-Ho, Jung, Seung-Min, Suh, Young Sun, Koh, Jung-Hee, Kwok, Seung-Ki, Ju, Ji Hyeon, Park, Kyung-Su, Park, Sung-Hwan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4381370/
https://www.ncbi.nlm.nih.gov/pubmed/25889813
http://dx.doi.org/10.1186/s13075-015-0593-6
_version_ 1782364441195577344
author Lee, Jennifer
Lee, Ji-Yeon
Lee, Jae-Ho
Jung, Seung-Min
Suh, Young Sun
Koh, Jung-Hee
Kwok, Seung-Ki
Ju, Ji Hyeon
Park, Kyung-Su
Park, Sung-Hwan
author_facet Lee, Jennifer
Lee, Ji-Yeon
Lee, Jae-Ho
Jung, Seung-Min
Suh, Young Sun
Koh, Jung-Hee
Kwok, Seung-Ki
Ju, Ji Hyeon
Park, Kyung-Su
Park, Sung-Hwan
author_sort Lee, Jennifer
collection PubMed
description INTRODUCTION: Gout is a chronic inflammatory disease the development of which is associated with obesity-induced metabolic abnormalities. However, a substantial number of non-obese patients (body mass index [BMI] <25 kg/m(2)) also develop gout in Korea. It was suggested that accumulation of visceral fat rather than subcutaneous fat is associated with metabolic abnormalities and hyperuricemia in patients with gout; therefore, we hypothesized that visceral fat accumulation was increased in non-obese gout patients. METHODS: One hundred and three male patients with primary gout and 204 age-matched healthy controls who attended a health check-up examination were recruited after the review of medical charts. The visceral fat area (VFA) was measured using the bioelectrical impedance analysis (BIA) method, and a VFA >100 cm(2) was defined as visceral fat obesity (VFO). The frequency of VFO was compared in patients and control groups. The frequencies of metabolic syndrome and related parameters were also investigated. RESULTS: BMI, waist circumference, total fat mass, serum triglycerides, and serum glucose levels were significantly greater in patients compared with controls. VFA and the prevalence of VFO was increased in gout patients compared with controls. There were positive correlations between VFA and serum triglyceride levels and serum glucose levels. Multivariate regression analysis revealed that VFO is an independent risk factor for gout (odds ratio 2.488, 95% confidence interval 1.041–4.435). In non-obese subgroup analyses (gout patients, n = 38; healthy controls, n = 150), VFA (98.7 ± 19.3 vs. 91.0 ± 16.7, P = 0.016) and the frequency of VFO (47.4 vs. 27.3%, P = 0.017) remained significantly higher in gout patients. There was no difference in either BMI or total fat mass between patients and controls in the non-obese subgroup. The prevalence of metabolic syndrome in patients with gout was 31.7% (33/104), compared with 13.2% (5/38) in the non-obese subgroup according to modified ATP III criteria. CONCLUSION: VFO, measured using BIA, is observed more frequently in patients with primary gout compared with healthy controls, even in non-obese individuals. Therefore, VFO might more properly represent metabolic derangements in patients with gout than general obesity.
format Online
Article
Text
id pubmed-4381370
institution National Center for Biotechnology Information
language English
publishDate 2015
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-43813702015-04-02 Visceral fat obesity is highly associated with primary gout in a metabolically obese but normal weighted population: a case control study Lee, Jennifer Lee, Ji-Yeon Lee, Jae-Ho Jung, Seung-Min Suh, Young Sun Koh, Jung-Hee Kwok, Seung-Ki Ju, Ji Hyeon Park, Kyung-Su Park, Sung-Hwan Arthritis Res Ther Research Article INTRODUCTION: Gout is a chronic inflammatory disease the development of which is associated with obesity-induced metabolic abnormalities. However, a substantial number of non-obese patients (body mass index [BMI] <25 kg/m(2)) also develop gout in Korea. It was suggested that accumulation of visceral fat rather than subcutaneous fat is associated with metabolic abnormalities and hyperuricemia in patients with gout; therefore, we hypothesized that visceral fat accumulation was increased in non-obese gout patients. METHODS: One hundred and three male patients with primary gout and 204 age-matched healthy controls who attended a health check-up examination were recruited after the review of medical charts. The visceral fat area (VFA) was measured using the bioelectrical impedance analysis (BIA) method, and a VFA >100 cm(2) was defined as visceral fat obesity (VFO). The frequency of VFO was compared in patients and control groups. The frequencies of metabolic syndrome and related parameters were also investigated. RESULTS: BMI, waist circumference, total fat mass, serum triglycerides, and serum glucose levels were significantly greater in patients compared with controls. VFA and the prevalence of VFO was increased in gout patients compared with controls. There were positive correlations between VFA and serum triglyceride levels and serum glucose levels. Multivariate regression analysis revealed that VFO is an independent risk factor for gout (odds ratio 2.488, 95% confidence interval 1.041–4.435). In non-obese subgroup analyses (gout patients, n = 38; healthy controls, n = 150), VFA (98.7 ± 19.3 vs. 91.0 ± 16.7, P = 0.016) and the frequency of VFO (47.4 vs. 27.3%, P = 0.017) remained significantly higher in gout patients. There was no difference in either BMI or total fat mass between patients and controls in the non-obese subgroup. The prevalence of metabolic syndrome in patients with gout was 31.7% (33/104), compared with 13.2% (5/38) in the non-obese subgroup according to modified ATP III criteria. CONCLUSION: VFO, measured using BIA, is observed more frequently in patients with primary gout compared with healthy controls, even in non-obese individuals. Therefore, VFO might more properly represent metabolic derangements in patients with gout than general obesity. BioMed Central 2015-03-24 2015 /pmc/articles/PMC4381370/ /pubmed/25889813 http://dx.doi.org/10.1186/s13075-015-0593-6 Text en © Lee et al.; licensee BioMed Central. 2015 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Lee, Jennifer
Lee, Ji-Yeon
Lee, Jae-Ho
Jung, Seung-Min
Suh, Young Sun
Koh, Jung-Hee
Kwok, Seung-Ki
Ju, Ji Hyeon
Park, Kyung-Su
Park, Sung-Hwan
Visceral fat obesity is highly associated with primary gout in a metabolically obese but normal weighted population: a case control study
title Visceral fat obesity is highly associated with primary gout in a metabolically obese but normal weighted population: a case control study
title_full Visceral fat obesity is highly associated with primary gout in a metabolically obese but normal weighted population: a case control study
title_fullStr Visceral fat obesity is highly associated with primary gout in a metabolically obese but normal weighted population: a case control study
title_full_unstemmed Visceral fat obesity is highly associated with primary gout in a metabolically obese but normal weighted population: a case control study
title_short Visceral fat obesity is highly associated with primary gout in a metabolically obese but normal weighted population: a case control study
title_sort visceral fat obesity is highly associated with primary gout in a metabolically obese but normal weighted population: a case control study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4381370/
https://www.ncbi.nlm.nih.gov/pubmed/25889813
http://dx.doi.org/10.1186/s13075-015-0593-6
work_keys_str_mv AT leejennifer visceralfatobesityishighlyassociatedwithprimarygoutinametabolicallyobesebutnormalweightedpopulationacasecontrolstudy
AT leejiyeon visceralfatobesityishighlyassociatedwithprimarygoutinametabolicallyobesebutnormalweightedpopulationacasecontrolstudy
AT leejaeho visceralfatobesityishighlyassociatedwithprimarygoutinametabolicallyobesebutnormalweightedpopulationacasecontrolstudy
AT jungseungmin visceralfatobesityishighlyassociatedwithprimarygoutinametabolicallyobesebutnormalweightedpopulationacasecontrolstudy
AT suhyoungsun visceralfatobesityishighlyassociatedwithprimarygoutinametabolicallyobesebutnormalweightedpopulationacasecontrolstudy
AT kohjunghee visceralfatobesityishighlyassociatedwithprimarygoutinametabolicallyobesebutnormalweightedpopulationacasecontrolstudy
AT kwokseungki visceralfatobesityishighlyassociatedwithprimarygoutinametabolicallyobesebutnormalweightedpopulationacasecontrolstudy
AT jujihyeon visceralfatobesityishighlyassociatedwithprimarygoutinametabolicallyobesebutnormalweightedpopulationacasecontrolstudy
AT parkkyungsu visceralfatobesityishighlyassociatedwithprimarygoutinametabolicallyobesebutnormalweightedpopulationacasecontrolstudy
AT parksunghwan visceralfatobesityishighlyassociatedwithprimarygoutinametabolicallyobesebutnormalweightedpopulationacasecontrolstudy