The inactive X chromosome is epigenetically unstable and transcriptionally labile in breast cancer

Disappearance of the Barr body is considered a hallmark of cancer, although whether this corresponds to genetic loss or to epigenetic instability and transcriptional reactivation is unclear. Here we show that breast tumors and cell lines frequently display major epigenetic instability of the inactiv...

Descripción completa

Detalles Bibliográficos
Autores principales: Chaligné, Ronan, Popova, Tatiana, Mendoza-Parra, Marco-Antonio, Saleem, Mohamed-Ashick M., Gentien, David, Ban, Kristen, Piolot, Tristan, Leroy, Olivier, Mariani, Odette, Gronemeyer, Hinrich, Vincent-Salomon, Anne, Stern, Marc-Henri, Heard, Edith
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2015
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4381521/
https://www.ncbi.nlm.nih.gov/pubmed/25653311
http://dx.doi.org/10.1101/gr.185926.114

Ejemplares similares

Ejemplares similares