Targeting ornithine decarboxylase reverses the LIN28/Let-7 axis and inhibits glycolytic metabolism in neuroblastoma

LIN28 has emerged as an oncogenic driver in a number of cancers, including neuroblastoma (NB). Overexpression of LIN28 correlates with poor outcome in NB, therefore drugs that impact the LIN28/Let-7 pathway could be beneficial in treating NB patients. The LIN28/Let-7 pathway affects many cellular pr...

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Detalles Bibliográficos
Autores principales: Lozier, Ann M., Rich, Maria E., Grawe, Anissa Pedersen, Peck, Anderson S., Zhao, Ping, Chang, Anthony Ting-Tung, Bond, Jeffrey P., Sholler, Giselle Saulnier
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2014
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4381588/
https://www.ncbi.nlm.nih.gov/pubmed/25415050

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