Truncated RAF kinases drive resistance to MET inhibition in MET-addicted cancer cells

Constitutively active receptor tyrosine kinases (RTKs) are known oncogenic drivers and provide valuable therapeutic targets in many cancer types. However, clinical efficacy of RTK inhibitors is limited by intrinsic and acquired resistance. To identify genes conferring resistance to inhibition of the...

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Detalles Bibliográficos
Autores principales: Petti, Consalvo, Picco, Gabriele, Martelli, Maria Luisa, Trisolini, Elena, Bucci, Enrico, Perera, Timothy, Isella, Claudio, Medico, Enzo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2014
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4381590/
https://www.ncbi.nlm.nih.gov/pubmed/25473895

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