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Gene expression analysis of head and neck squamous cell carcinoma survival and recurrence

The squamous cell carcinomas represent about 90 % of all head and neck cancers, ranking the sixth most common human cancer. Approximately 450,000 of new cases of head and neck squamous cell carcinoma (HNSCC) are diagnosed every year. Unfortunately, because of diagnosis at the advanced stages and ear...

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Autores principales: Zhi, Xu, Lamperska, Katarzyna, Golusinski, Paweł, Schork, Nicholas J., Luczewski, Lukasz, Kolenda, Tomasz, Golusinski, Wojciech, Masternak, Michal M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4381614/
https://www.ncbi.nlm.nih.gov/pubmed/25575813
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author Zhi, Xu
Lamperska, Katarzyna
Golusinski, Paweł
Schork, Nicholas J.
Luczewski, Lukasz
Kolenda, Tomasz
Golusinski, Wojciech
Masternak, Michal M.
author_facet Zhi, Xu
Lamperska, Katarzyna
Golusinski, Paweł
Schork, Nicholas J.
Luczewski, Lukasz
Kolenda, Tomasz
Golusinski, Wojciech
Masternak, Michal M.
author_sort Zhi, Xu
collection PubMed
description The squamous cell carcinomas represent about 90 % of all head and neck cancers, ranking the sixth most common human cancer. Approximately 450,000 of new cases of head and neck squamous cell carcinoma (HNSCC) are diagnosed every year. Unfortunately, because of diagnosis at the advanced stages and early metastasis to the lymph nodes, the HNSCC is associated with very high death rate. Identification of signature biomarkers and molecularly targeted therapies could provide more effective and specific cancer treatment, prevent recurrence, and increase survival rate. We used paired tumor and adjacent normal tissue samples to screen with RT² Profiler™ PCR Array Human Cancer PathwayFinder(TM). Total of 20 up-regulated genes and two down-regulated genes were screened out. Out of 22 genes, 12 genes were subsequently validated to be significantly altered in the HNSCC; the samples were from all 41 patients. Five year survival and recurrence selected genes that could represent the biomarkers of survival and recurrence of the disease. We believe that comprehensive understanding of the unique genetic characteristics of HNSCC could provide novel diagnostic biomarkers and meet the requirement for molecular-targeted therapy for the HNSCC.
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spelling pubmed-43816142015-04-09 Gene expression analysis of head and neck squamous cell carcinoma survival and recurrence Zhi, Xu Lamperska, Katarzyna Golusinski, Paweł Schork, Nicholas J. Luczewski, Lukasz Kolenda, Tomasz Golusinski, Wojciech Masternak, Michal M. Oncotarget Clinical Research Paper The squamous cell carcinomas represent about 90 % of all head and neck cancers, ranking the sixth most common human cancer. Approximately 450,000 of new cases of head and neck squamous cell carcinoma (HNSCC) are diagnosed every year. Unfortunately, because of diagnosis at the advanced stages and early metastasis to the lymph nodes, the HNSCC is associated with very high death rate. Identification of signature biomarkers and molecularly targeted therapies could provide more effective and specific cancer treatment, prevent recurrence, and increase survival rate. We used paired tumor and adjacent normal tissue samples to screen with RT² Profiler™ PCR Array Human Cancer PathwayFinder(TM). Total of 20 up-regulated genes and two down-regulated genes were screened out. Out of 22 genes, 12 genes were subsequently validated to be significantly altered in the HNSCC; the samples were from all 41 patients. Five year survival and recurrence selected genes that could represent the biomarkers of survival and recurrence of the disease. We believe that comprehensive understanding of the unique genetic characteristics of HNSCC could provide novel diagnostic biomarkers and meet the requirement for molecular-targeted therapy for the HNSCC. Impact Journals LLC 2014-11-16 /pmc/articles/PMC4381614/ /pubmed/25575813 Text en Copyright: © 2015 Zhi et al. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Clinical Research Paper
Zhi, Xu
Lamperska, Katarzyna
Golusinski, Paweł
Schork, Nicholas J.
Luczewski, Lukasz
Kolenda, Tomasz
Golusinski, Wojciech
Masternak, Michal M.
Gene expression analysis of head and neck squamous cell carcinoma survival and recurrence
title Gene expression analysis of head and neck squamous cell carcinoma survival and recurrence
title_full Gene expression analysis of head and neck squamous cell carcinoma survival and recurrence
title_fullStr Gene expression analysis of head and neck squamous cell carcinoma survival and recurrence
title_full_unstemmed Gene expression analysis of head and neck squamous cell carcinoma survival and recurrence
title_short Gene expression analysis of head and neck squamous cell carcinoma survival and recurrence
title_sort gene expression analysis of head and neck squamous cell carcinoma survival and recurrence
topic Clinical Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4381614/
https://www.ncbi.nlm.nih.gov/pubmed/25575813
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