A Case of Coronary Vasospasm after Repeat Rituximab Infusion

Coronary artery vasospasm (CAV) can be triggered by medication reactions. CAV occurring after multiple exposures to rituximab has not been previously described. A 61-year-old woman with no cardiac risk factors was treated with the sixth cycle of gemcitabine, cisplatin, dexamethasone, and rituximab t...

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Detalles Bibliográficos
Autores principales: Ke, Calvin, Khosla, Amit, Davis, Margot K., Hague, Cameron, Toma, Mustafa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2015
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4381723/
https://www.ncbi.nlm.nih.gov/pubmed/25866684
http://dx.doi.org/10.1155/2015/523149
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author Ke, Calvin
Khosla, Amit
Davis, Margot K.
Hague, Cameron
Toma, Mustafa
author_facet Ke, Calvin
Khosla, Amit
Davis, Margot K.
Hague, Cameron
Toma, Mustafa
author_sort Ke, Calvin
collection PubMed
description Coronary artery vasospasm (CAV) can be triggered by medication reactions. CAV occurring after multiple exposures to rituximab has not been previously described. A 61-year-old woman with no cardiac risk factors was treated with the sixth cycle of gemcitabine, cisplatin, dexamethasone, and rituximab therapy. Fifteen minutes after rituximab infusion commenced, she developed typical cardiac chest pain with ST segment elevations on electrocardiogram. Angiogram revealed evidence of coronary vasospasm. The patient was successfully treated with amlodipine. This case underlines the importance of monitoring cardiac side effects of rituximab therapy, even after multiple cycles.
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spelling pubmed-43817232015-04-12 A Case of Coronary Vasospasm after Repeat Rituximab Infusion Ke, Calvin Khosla, Amit Davis, Margot K. Hague, Cameron Toma, Mustafa Case Rep Cardiol Case Report Coronary artery vasospasm (CAV) can be triggered by medication reactions. CAV occurring after multiple exposures to rituximab has not been previously described. A 61-year-old woman with no cardiac risk factors was treated with the sixth cycle of gemcitabine, cisplatin, dexamethasone, and rituximab therapy. Fifteen minutes after rituximab infusion commenced, she developed typical cardiac chest pain with ST segment elevations on electrocardiogram. Angiogram revealed evidence of coronary vasospasm. The patient was successfully treated with amlodipine. This case underlines the importance of monitoring cardiac side effects of rituximab therapy, even after multiple cycles. Hindawi Publishing Corporation 2015 2015-03-18 /pmc/articles/PMC4381723/ /pubmed/25866684 http://dx.doi.org/10.1155/2015/523149 Text en Copyright © 2015 Calvin Ke et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Ke, Calvin
Khosla, Amit
Davis, Margot K.
Hague, Cameron
Toma, Mustafa
A Case of Coronary Vasospasm after Repeat Rituximab Infusion
title A Case of Coronary Vasospasm after Repeat Rituximab Infusion
title_full A Case of Coronary Vasospasm after Repeat Rituximab Infusion
title_fullStr A Case of Coronary Vasospasm after Repeat Rituximab Infusion
title_full_unstemmed A Case of Coronary Vasospasm after Repeat Rituximab Infusion
title_short A Case of Coronary Vasospasm after Repeat Rituximab Infusion
title_sort case of coronary vasospasm after repeat rituximab infusion
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4381723/
https://www.ncbi.nlm.nih.gov/pubmed/25866684
http://dx.doi.org/10.1155/2015/523149
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