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A novel N-terminal extension in mitochondrial TRAP1 serves as a thermal regulator of chaperone activity

Hsp90 is a conserved chaperone that facilitates protein homeostasis. Our crystal structure of the mitochondrial Hsp90, TRAP1, revealed an extension of the N-terminal β-strand previously shown to cross between protomers in the closed state. In this study, we address the regulatory function of this ex...

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Detalles Bibliográficos
Autores principales:	Partridge, James R, Lavery, Laura A, Elnatan, Daniel, Naber, Nariman, Cooke, Roger, Agard, David A
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2014
Materias:	Biochemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4381864/ https://www.ncbi.nlm.nih.gov/pubmed/25531069 http://dx.doi.org/10.7554/eLife.03487

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