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Recent progress in fungus-derived bioactive agents for targeting of signaling machinery in cancer cells
It is becoming increasingly understood that tumor cells may have different mutations and dependencies on diverse intracellular signaling cascades for survival or metastatic potential. Overexpression of oncogenes, inactivation of tumor suppressor genes, genetic/epigenetic mutations, genomic instabili...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove Medical Press
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4381899/ https://www.ncbi.nlm.nih.gov/pubmed/25848216 http://dx.doi.org/10.2147/DDDT.S77341 |
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author | Lin, Xiukun Farooqi, Ammad Ahmad Ismail, Muhammad |
author_facet | Lin, Xiukun Farooqi, Ammad Ahmad Ismail, Muhammad |
author_sort | Lin, Xiukun |
collection | PubMed |
description | It is becoming increasingly understood that tumor cells may have different mutations and dependencies on diverse intracellular signaling cascades for survival or metastatic potential. Overexpression of oncogenes, inactivation of tumor suppressor genes, genetic/epigenetic mutations, genomic instability, and loss of apoptotic cell death are some of the mechanisms that have been widely investigated in molecular oncology. We partition this multicomponent review into the most recent evidence on the anticancer activity of fungal substances obtained from in vitro and xenografted models, and these fungal substances modulate expression of oncogenic and tumor suppressor miRNAs. There are some outstanding questions regarding fungus-derived chemical-induced modulation of intracellular signaling networks in different cancer cell lines and preclinical models. Certain hints have emerged, emphasizing mechanisms via which apoptosis can be restored in TRAIL-resistant cancer cells. Reconceptualization of the knowledge obtained from these emerging areas of research will enable us to potentially identify natural agents with notable anticancer activity and minimal off-target effects. Integration of experimentally verified evidence obtained from cancer cell line gene expression with large-scale functional screening results and pharmacological sensitivity data will be helpful in identification of therapeutics with substantial efficacy. New tools and technologies will further deepen our understanding of the signaling networks that underlie the development of cancer, metastasis, and resistance to different therapeutics at both a personal and systems-wide level. |
format | Online Article Text |
id | pubmed-4381899 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Dove Medical Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-43818992015-04-06 Recent progress in fungus-derived bioactive agents for targeting of signaling machinery in cancer cells Lin, Xiukun Farooqi, Ammad Ahmad Ismail, Muhammad Drug Des Devel Ther Review It is becoming increasingly understood that tumor cells may have different mutations and dependencies on diverse intracellular signaling cascades for survival or metastatic potential. Overexpression of oncogenes, inactivation of tumor suppressor genes, genetic/epigenetic mutations, genomic instability, and loss of apoptotic cell death are some of the mechanisms that have been widely investigated in molecular oncology. We partition this multicomponent review into the most recent evidence on the anticancer activity of fungal substances obtained from in vitro and xenografted models, and these fungal substances modulate expression of oncogenic and tumor suppressor miRNAs. There are some outstanding questions regarding fungus-derived chemical-induced modulation of intracellular signaling networks in different cancer cell lines and preclinical models. Certain hints have emerged, emphasizing mechanisms via which apoptosis can be restored in TRAIL-resistant cancer cells. Reconceptualization of the knowledge obtained from these emerging areas of research will enable us to potentially identify natural agents with notable anticancer activity and minimal off-target effects. Integration of experimentally verified evidence obtained from cancer cell line gene expression with large-scale functional screening results and pharmacological sensitivity data will be helpful in identification of therapeutics with substantial efficacy. New tools and technologies will further deepen our understanding of the signaling networks that underlie the development of cancer, metastasis, and resistance to different therapeutics at both a personal and systems-wide level. Dove Medical Press 2015-03-26 /pmc/articles/PMC4381899/ /pubmed/25848216 http://dx.doi.org/10.2147/DDDT.S77341 Text en © 2015 Lin et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. |
spellingShingle | Review Lin, Xiukun Farooqi, Ammad Ahmad Ismail, Muhammad Recent progress in fungus-derived bioactive agents for targeting of signaling machinery in cancer cells |
title | Recent progress in fungus-derived bioactive agents for targeting of signaling machinery in cancer cells |
title_full | Recent progress in fungus-derived bioactive agents for targeting of signaling machinery in cancer cells |
title_fullStr | Recent progress in fungus-derived bioactive agents for targeting of signaling machinery in cancer cells |
title_full_unstemmed | Recent progress in fungus-derived bioactive agents for targeting of signaling machinery in cancer cells |
title_short | Recent progress in fungus-derived bioactive agents for targeting of signaling machinery in cancer cells |
title_sort | recent progress in fungus-derived bioactive agents for targeting of signaling machinery in cancer cells |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4381899/ https://www.ncbi.nlm.nih.gov/pubmed/25848216 http://dx.doi.org/10.2147/DDDT.S77341 |
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