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Recent progress in fungus-derived bioactive agents for targeting of signaling machinery in cancer cells

It is becoming increasingly understood that tumor cells may have different mutations and dependencies on diverse intracellular signaling cascades for survival or metastatic potential. Overexpression of oncogenes, inactivation of tumor suppressor genes, genetic/epigenetic mutations, genomic instabili...

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Detalles Bibliográficos
Autores principales: Lin, Xiukun, Farooqi, Ammad Ahmad, Ismail, Muhammad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4381899/
https://www.ncbi.nlm.nih.gov/pubmed/25848216
http://dx.doi.org/10.2147/DDDT.S77341
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author Lin, Xiukun
Farooqi, Ammad Ahmad
Ismail, Muhammad
author_facet Lin, Xiukun
Farooqi, Ammad Ahmad
Ismail, Muhammad
author_sort Lin, Xiukun
collection PubMed
description It is becoming increasingly understood that tumor cells may have different mutations and dependencies on diverse intracellular signaling cascades for survival or metastatic potential. Overexpression of oncogenes, inactivation of tumor suppressor genes, genetic/epigenetic mutations, genomic instability, and loss of apoptotic cell death are some of the mechanisms that have been widely investigated in molecular oncology. We partition this multicomponent review into the most recent evidence on the anticancer activity of fungal substances obtained from in vitro and xenografted models, and these fungal substances modulate expression of oncogenic and tumor suppressor miRNAs. There are some outstanding questions regarding fungus-derived chemical-induced modulation of intracellular signaling networks in different cancer cell lines and preclinical models. Certain hints have emerged, emphasizing mechanisms via which apoptosis can be restored in TRAIL-resistant cancer cells. Reconceptualization of the knowledge obtained from these emerging areas of research will enable us to potentially identify natural agents with notable anticancer activity and minimal off-target effects. Integration of experimentally verified evidence obtained from cancer cell line gene expression with large-scale functional screening results and pharmacological sensitivity data will be helpful in identification of therapeutics with substantial efficacy. New tools and technologies will further deepen our understanding of the signaling networks that underlie the development of cancer, metastasis, and resistance to different therapeutics at both a personal and systems-wide level.
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spelling pubmed-43818992015-04-06 Recent progress in fungus-derived bioactive agents for targeting of signaling machinery in cancer cells Lin, Xiukun Farooqi, Ammad Ahmad Ismail, Muhammad Drug Des Devel Ther Review It is becoming increasingly understood that tumor cells may have different mutations and dependencies on diverse intracellular signaling cascades for survival or metastatic potential. Overexpression of oncogenes, inactivation of tumor suppressor genes, genetic/epigenetic mutations, genomic instability, and loss of apoptotic cell death are some of the mechanisms that have been widely investigated in molecular oncology. We partition this multicomponent review into the most recent evidence on the anticancer activity of fungal substances obtained from in vitro and xenografted models, and these fungal substances modulate expression of oncogenic and tumor suppressor miRNAs. There are some outstanding questions regarding fungus-derived chemical-induced modulation of intracellular signaling networks in different cancer cell lines and preclinical models. Certain hints have emerged, emphasizing mechanisms via which apoptosis can be restored in TRAIL-resistant cancer cells. Reconceptualization of the knowledge obtained from these emerging areas of research will enable us to potentially identify natural agents with notable anticancer activity and minimal off-target effects. Integration of experimentally verified evidence obtained from cancer cell line gene expression with large-scale functional screening results and pharmacological sensitivity data will be helpful in identification of therapeutics with substantial efficacy. New tools and technologies will further deepen our understanding of the signaling networks that underlie the development of cancer, metastasis, and resistance to different therapeutics at both a personal and systems-wide level. Dove Medical Press 2015-03-26 /pmc/articles/PMC4381899/ /pubmed/25848216 http://dx.doi.org/10.2147/DDDT.S77341 Text en © 2015 Lin et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
spellingShingle Review
Lin, Xiukun
Farooqi, Ammad Ahmad
Ismail, Muhammad
Recent progress in fungus-derived bioactive agents for targeting of signaling machinery in cancer cells
title Recent progress in fungus-derived bioactive agents for targeting of signaling machinery in cancer cells
title_full Recent progress in fungus-derived bioactive agents for targeting of signaling machinery in cancer cells
title_fullStr Recent progress in fungus-derived bioactive agents for targeting of signaling machinery in cancer cells
title_full_unstemmed Recent progress in fungus-derived bioactive agents for targeting of signaling machinery in cancer cells
title_short Recent progress in fungus-derived bioactive agents for targeting of signaling machinery in cancer cells
title_sort recent progress in fungus-derived bioactive agents for targeting of signaling machinery in cancer cells
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4381899/
https://www.ncbi.nlm.nih.gov/pubmed/25848216
http://dx.doi.org/10.2147/DDDT.S77341
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