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High-throughput engineering of a mammalian genome reveals building principles of methylation states at CG rich regions
The majority of mammalian promoters are CpG islands; regions of high CG density that require protection from DNA methylation to be functional. Importantly, how sequence architecture mediates this unmethylated state remains unclear. To address this question in a comprehensive manner, we developed a m...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
eLife Sciences Publications, Ltd
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4381937/ https://www.ncbi.nlm.nih.gov/pubmed/25259795 http://dx.doi.org/10.7554/eLife.04094 |