Cargando…

3D imaging of Sox2 enhancer clusters in embryonic stem cells

Combinatorial cis-regulatory networks encoded in animal genomes represent the foundational gene expression mechanism for directing cell-fate commitment and maintenance of cell identity by transcription factors (TFs). However, the 3D spatial organization of cis-elements and how such sub-nuclear struc...

Descripción completa

Detalles Bibliográficos
Autores principales:	Liu, Zhe, Legant, Wesley R, Chen, Bi-Chang, Li, Li, Grimm, Jonathan B, Lavis, Luke D, Betzig, Eric, Tjian, Robert
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2014
Materias:	Biophysics and Structural Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4381973/ https://www.ncbi.nlm.nih.gov/pubmed/25537195 http://dx.doi.org/10.7554/eLife.04236

Ejemplares similares

Real-time imaging of Huntingtin aggregates diverting target search and gene transcription
por: Li, Li, et al.
Publicado: (2016)

Single-molecule tracking of the transcription cycle by sub-second RNA detection
por: Zhang, Zhengjian, et al.
Publicado: (2014)

Robust model-based analysis of single-particle tracking experiments with Spot-On
por: Hansen, Anders S, et al.
Publicado: (2018)

RNA Polymerase II cluster dynamics predict mRNA output in living cells
por: Cho, Won-Ki, et al.
Publicado: (2016)

Live-cell single-molecule tracking reveals co-recognition of H3K27me3 and DNA targets polycomb Cbx7-PRC1 to chromatin
por: Zhen, Chao Yu, et al.
Publicado: (2016)

CTCF and cohesin regulate chromatin loop stability with distinct dynamics
por: Hansen, Anders S, et al.
Publicado: (2017)

Nuclear microenvironments modulate transcription from low-affinity enhancers
por: Tsai, Albert, et al.
Publicado: (2017)

Disordered clusters of Bak dimers rupture mitochondria during apoptosis
por: Uren, Rachel T, et al.
Publicado: (2017)

Phase transitions of multivalent proteins can promote clustering of membrane receptors
por: Banjade, Sudeep, et al.
Publicado: (2014)

Carbofluoresceins and Carborhodamines as Scaffolds for High-Contrast Fluorogenic Probes
por: Grimm, Jonathan B., et al.
Publicado: (2013)

Ca(2+) entry into neurons is facilitated by cooperative gating of clustered Ca(V)1.3 channels
por: Moreno, Claudia M, et al.
Publicado: (2016)

Enhancer additivity and non-additivity are determined by enhancer strength in the Drosophila embryo
por: Bothma, Jacques P, et al.
Publicado: (2015)

Building a super elongation complex for HIV
por: Hill, Christopher P, et al.
Publicado: (2013)

Direct measurement of conformational strain energy in protofilaments curling outward from disassembling microtubule tips
por: Driver, Jonathan W, et al.
Publicado: (2017)

Native α-synuclein induces clustering of synaptic-vesicle mimics via binding to phospholipids and synaptobrevin-2/VAMP2
por: Diao, Jiajie, et al.
Publicado: (2013)

Proximal clustering between BK and Ca(V)1.3 channels promotes functional coupling and BK channel activation at low voltage
por: Vivas, Oscar, et al.
Publicado: (2017)

May I check your cap?
por: Geyer, Elisabeth A, et al.
Publicado: (2016)

ETO family protein Mtgr1 mediates Prdm14 functions in stem cell maintenance and primordial germ cell formation
por: Nady, Nataliya, et al.
Publicado: (2015)

Kinesin Kip2 enhances microtubule growth in vitro through length-dependent feedback on polymerization and catastrophe
por: Hibbel, Anneke, et al.
Publicado: (2015)

Folding behavior of a T-shaped, ribosome-binding translation enhancer implicated in a wide-spread conformational switch
por: Le, My-Tra, et al.
Publicado: (2017)

Correction: Sequential conformational rearrangements in flavivirus membrane fusion
por: Chao, Luke H, et al.
Publicado: (2015)

Sequential conformational rearrangements in flavivirus membrane fusion
por: Chao, Luke H, et al.
Publicado: (2014)

Knockout of Slo2.2 enhances itch, abolishes K(Na) current, and increases action potential firing frequency in DRG neurons
por: Martinez-Espinosa, Pedro L, et al.
Publicado: (2015)

High density three-dimensional localization microscopy across large volumes
por: Legant, Wesley R., et al.
Publicado: (2016)

A mutation uncouples the tubulin conformational and GTPase cycles, revealing allosteric control of microtubule dynamics
por: Geyer, Elisabeth A, et al.
Publicado: (2015)

Changes in the free-energy landscape of p38α MAP kinase through its canonical activation and binding events as studied by enhanced molecular dynamics simulations
por: Kuzmanic, Antonija, et al.
Publicado: (2017)

A tethered delivery mechanism explains the catalytic action of a microtubule polymerase
por: Ayaz, Pelin, et al.
Publicado: (2014)

Looking inside the cell
por: Arakel, Eric C, et al.
Publicado: (2017)

Checkpoint proteins come under scrutiny
por: Mora-Santos, Maria, et al.
Publicado: (2013)

ER retention is imposed by COPII protein sorting and attenuated by 4-phenylbutyrate
por: Ma, Wenfu, et al.
Publicado: (2017)

An alternative to force
por: Patel, Amanda, et al.
Publicado: (2015)

Mechanical design principles of a mitotic spindle
por: Ward, Jonathan J, et al.
Publicado: (2014)

Simulated annealing approach to vascular structure with application to the coronary arteries
por: Keelan, Jonathan, et al.
Publicado: (2016)

A large field of view two-photon mesoscope with subcellular resolution for in vivo imaging
por: Sofroniew, Nicholas James, et al.
Publicado: (2016)

Structural basis for the assembly of the mitotic motor Kinesin-5 into bipolar tetramers
por: Scholey, Jessica E, et al.
Publicado: (2014)

Drastic changes in conformational dynamics of the antiterminator M2-1 regulate transcription efficiency in Pneumovirinae
por: Leyrat, Cedric, et al.
Publicado: (2014)

Bringing dead proteins back to life
por: A Wustman, Brandon, et al.
Publicado: (2014)

Her2 activation mechanism reflects evolutionary preservation of asymmetric ectodomain dimers in the human EGFR family
por: Arkhipov, Anton, et al.
Publicado: (2013)

Mutational scanning reveals the determinants of protein insertion and association energetics in the plasma membrane
por: Elazar, Assaf, et al.
Publicado: (2016)

Structure and functional properties of Norrin mimic Wnt for signalling with Frizzled4, Lrp5/6, and proteoglycan
por: Chang, Tao-Hsin, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_l21j5tbv7i6ami9n2lgpapm3tp