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Left Truncation Bias as a Potential Explanation for the Protective Effect of Smoking on Preeclampsia

BACKGROUND: We carried out a study to examine whether left truncation bias could explain the negative association between smoking and preeclampsia. METHODS: Monte Carlo and other simulation models were used to determine the effect of differential rates of early pregnancy loss among smokers on the re...

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Detalles Bibliográficos
Autores principales: Lisonkova, Sarka, Joseph, K. S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4381982/
https://www.ncbi.nlm.nih.gov/pubmed/25695352
http://dx.doi.org/10.1097/EDE.0000000000000268
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author Lisonkova, Sarka
Joseph, K. S.
author_facet Lisonkova, Sarka
Joseph, K. S.
author_sort Lisonkova, Sarka
collection PubMed
description BACKGROUND: We carried out a study to examine whether left truncation bias could explain the negative association between smoking and preeclampsia. METHODS: Monte Carlo and other simulation models were used to determine the effect of differential rates of early pregnancy loss among smokers on the relation between smoking and preeclampsia at ≥20 weeks’ gestation. Assumptions included no association between smoking and the abnormal placentation that characterizes preeclampsia, and higher rates of early pregnancy loss among smokers, pregnancies with abnormal placentation, and smokers with abnormal placentation. RESULTS: Monte Carlo simulation yielded a rate ratio for preeclampsia, given smoking of 0.85 (95% confidence interval = 0.73, 0.98). The protective effect of smoking was also evident in simulations that did not require assumptions about early pregnancy loss rates. CONCLUSION: Left truncation bias due to differential rates of early pregnancy loss among smokers is a plausible explanation for the inverse association between maternal smoking and preeclampsia.
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spelling pubmed-43819822015-04-10 Left Truncation Bias as a Potential Explanation for the Protective Effect of Smoking on Preeclampsia Lisonkova, Sarka Joseph, K. S. Epidemiology Reproduction BACKGROUND: We carried out a study to examine whether left truncation bias could explain the negative association between smoking and preeclampsia. METHODS: Monte Carlo and other simulation models were used to determine the effect of differential rates of early pregnancy loss among smokers on the relation between smoking and preeclampsia at ≥20 weeks’ gestation. Assumptions included no association between smoking and the abnormal placentation that characterizes preeclampsia, and higher rates of early pregnancy loss among smokers, pregnancies with abnormal placentation, and smokers with abnormal placentation. RESULTS: Monte Carlo simulation yielded a rate ratio for preeclampsia, given smoking of 0.85 (95% confidence interval = 0.73, 0.98). The protective effect of smoking was also evident in simulations that did not require assumptions about early pregnancy loss rates. CONCLUSION: Left truncation bias due to differential rates of early pregnancy loss among smokers is a plausible explanation for the inverse association between maternal smoking and preeclampsia. Lippincott Williams & Wilkins 2015-05 2015-04-02 /pmc/articles/PMC4381982/ /pubmed/25695352 http://dx.doi.org/10.1097/EDE.0000000000000268 Text en Copyright © 2015 Wolters Kluwer Health, Inc. All rights reserved. This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives 3.0 License, where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially.
spellingShingle Reproduction
Lisonkova, Sarka
Joseph, K. S.
Left Truncation Bias as a Potential Explanation for the Protective Effect of Smoking on Preeclampsia
title Left Truncation Bias as a Potential Explanation for the Protective Effect of Smoking on Preeclampsia
title_full Left Truncation Bias as a Potential Explanation for the Protective Effect of Smoking on Preeclampsia
title_fullStr Left Truncation Bias as a Potential Explanation for the Protective Effect of Smoking on Preeclampsia
title_full_unstemmed Left Truncation Bias as a Potential Explanation for the Protective Effect of Smoking on Preeclampsia
title_short Left Truncation Bias as a Potential Explanation for the Protective Effect of Smoking on Preeclampsia
title_sort left truncation bias as a potential explanation for the protective effect of smoking on preeclampsia
topic Reproduction
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4381982/
https://www.ncbi.nlm.nih.gov/pubmed/25695352
http://dx.doi.org/10.1097/EDE.0000000000000268
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