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Protective Effects of Non-Anticoagulant Activated Protein C Variant (D36A/L38D/A39V) in a Murine Model of Ischaemic Stroke

Ischaemic stroke is caused by occlusive thrombi in the cerebral vasculature. Although tissue-plasminogen activator (tPA) can be administered as thrombolytic therapy, it has major limitations, which include disruption of the blood-brain barrier and an increased risk of bleeding. Treatments that preve...

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Detalles Bibliográficos
Autores principales:	Andreou, Anna P., Efthymiou, Maria, Yu, Yao, Watts, Helena R., Noormohamed, Faruq H., Ma, Daqing, Lane, David A., Crawley, James TB
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4382112/ https://www.ncbi.nlm.nih.gov/pubmed/25830552 http://dx.doi.org/10.1371/journal.pone.0122410

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